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Long-term tolerabil...
Long-term tolerability and efficacy after initial PegIFN-alpha addition to dasatinib in CML-CP : Five-year follow-up of the NordCML007 study
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- Flygt, Hjalmar (författare)
- Univ Uppsala Hosp, Sweden; Univ Uppsala Hosp, Sweden
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- Söderlund, Stina (författare)
- Univ Uppsala Hosp, Sweden; Univ Uppsala Hosp, Sweden
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- Stentoft, Jesper (författare)
- Aarhus Univ Hosp, Denmark
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- Richter, Johan (författare)
- Skane Univ Hosp, Sweden
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- Koskenvesa, Perttu (författare)
- Univ Helsinki, Finland; Univ Helsinki, Finland
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- Mustjoki, Satu (författare)
- Univ Helsinki, Finland; Univ Helsinki, Finland; Univ Helsinki, Finland; Univ Helsinki, Finland
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- Majeed, Waleed (författare)
- Stavanger Univ Hosp, Norway
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- Lubking, Anna (författare)
- Skane Univ Hosp, Sweden
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- Dreimane, Arta (författare)
- Region Östergötland, Hematologiska kliniken US
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- Markevarn, Berit (författare)
- Umea Univ Hosp, Sweden
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- Stenke, Leif (författare)
- Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden
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- Myhr Eriksson, Kristina (författare)
- Sunderby Hosp, Sweden
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- Gjertsen, Bjorn Tore (författare)
- Haukeland Hosp, Norway
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- Gedde-Dahl, Tobias (författare)
- Natl Hosp Norway, Norway
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- Dimitrijevic, Andreja (författare)
- Odense Univ Hosp, Denmark
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- Udby, Lene (författare)
- Zealand Univ Hosp, Denmark
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- Olsson-Strömberg, Ulla (författare)
- Univ Uppsala Hosp, Sweden; Univ Uppsala Hosp, Sweden
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- Hjorth-Hansen, Henrik (författare)
- St Olavs Hosp Trondheim, Norway; Norwegian Univ Sci & Technol, Norway
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(creator_code:org_t)
- 2021-08-31
- 2021
- Engelska.
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Ingår i: European Journal of Haematology. - : Wiley-Blackwell. - 0902-4441 .- 1600-0609. ; 107:6, s. 617-623
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https://liu.diva-por... (primary) (Raw object)
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https://onlinelibrar...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Objectives Treatment-free remission (TFR) has emerged as a treatment goal in chronic myeloid leukemia in the chronic phase (CML-CP). Attempts to increase proportion of patients achieving TFR include combination of tyrosine kinase inhibitors (TKI) and other drugs. Interferon-alpha in addition to TKI has shown promising efficacy but with dose-dependent toxicity and discontinuations. NordCML007 was initiated to study the efficacy and safety of low dose pegylated IFN-alpha (PegIFN-alpha) in combination with dasatinib (DAS) in CML-CP. Methods Forty patients with newly diagnosed CML-CP were given DAS upfront. After month 3 (M3) 15 mu g/wk of PegIFN-alpha was added and increased to 25 mu g/wk from M7 until M15. DAS treatment was continued and adverse events and BCR-ABL1 qRT-PCR values were reported yearly after M24. Results from M1 to M18 have previously been published, and here we present long-term data. Results After 5 years of follow-up, there were no suspected unexpected serious adverse reactions, no increase in serosal effusions, no disease progressions and no CML-related deaths. Rates of MR3.0 (MMR), MR4.0 and MR4.5 were 84.6%, 64.1% and 51.3% respectively at M60, and 95% of patients reached MMR at some point during the study. Conclusion Initial addition of PegIFN-alpha to DAS shows good long-term efficacy without increased toxicity.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Nyckelord
- BCR-ABL Positive; chronic myelogenous leukemia; clinical trial; dasatinib; interferon-alpha
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- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Flygt, Hjalmar
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Söderlund, Stina
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Stentoft, Jesper
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Richter, Johan
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Koskenvesa, Pert ...
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Mustjoki, Satu
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visa fler...
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Majeed, Waleed
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Lubking, Anna
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Dreimane, Arta
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Markevarn, Berit
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Stenke, Leif
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Myhr Eriksson, K ...
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Gjertsen, Bjorn ...
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Gedde-Dahl, Tobi ...
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Dimitrijevic, An ...
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Udby, Lene
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Olsson-Strömberg ...
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Hjorth-Hansen, H ...
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