Sökning: onr:"swepub:oai:DiVA.org:liu-179467" >
Optical Brain Biops...
Optical Brain Biopsy with a Fluorescence and Vessel Tracing Probe
-
- Richter, Johan (författare)
- Linköpings universitet,Tekniska fakulteten,Avdelningen för medicinsk teknik,Region Östergötland, Neurokirurgiska kliniken US
-
- Haj-Hosseini, Neda (författare)
- Linköpings universitet,Avdelningen för medicinsk teknik,Tekniska fakulteten
-
- Milos, Peter (författare)
- Linköpings universitet,Medicinska fakulteten,Avdelningen för neurobiologi,Region Östergötland, Neurokirurgiska kliniken US
-
visa fler...
-
- Hallbeck, Martin (författare)
- Linköpings universitet,Avdelningen för neurobiologi,Medicinska fakulteten,Region Östergötland, Klinisk patologi
-
- Wårdell, Karin (författare)
- Linköpings universitet,Avdelningen för medicinsk teknik,Tekniska fakulteten,MINT
-
visa färre...
-
(creator_code:org_t)
- 2021-10
- 2021
- Engelska.
-
Ingår i: Operative Neurosurgery. - : Oxford University Press. - 2332-4252 .- 2332-4260. ; 21:4, s. 217-224
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://liu.diva-por... (primary) (Raw object)
-
https://academic.oup...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- BACKGROUND Accurate stereotactic biopsies of brain tumors are imperative for diagnosis and tailoring of the therapy. Repetitive needle insertions enhance risks of brain lesioning, hemorrhage, and complications due to prolonged procedure.OBJECTIVE To investigate clinical benefits of a combined 5-aminolaevulinic acid (5-ALA) fluorescence and laser Doppler flowmetry system for the detection of malignant brain tumor and blood vessels in stereotactic biopsies.METHODS Planning of targets and trajectories was followed by optical measurements in 20 patients, using the Leksell Stereotactic System and a manual insertion device. Fluorescence spectra, microvascular blood flow, and tissue grayness were recorded each millimeter along the paths. Biopsies were taken at preplanned positions. The diagnoses were compared with the fluorescence signals. The recordings were plotted against measurement positions and compared. Sites indicating a risk of hemorrhage were counted as well as the time for the procedures.RESULTS Signals were recorded along 28 trajectories, and 78 biopsies were collected. The final diagnosis showed 17 glioblastomas, 2 lymphomas, and 1 astrocytoma grade III. Fluorescence was seen along 23 of the paths with 4 having the peak of 5-ALA fluorescence 3 mm or more from the precalculated target. There was increased microcirculation in 40 of 905 measured positions. The measurement time for each trajectory was 5 to 10 min.CONCLUSION The probe provided direct feedback of increased blood flow along the trajectory and of malignant tissue in the vicinity of the target. The method can increase the precision and the safety of the biopsy procedure and reduce time.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik -- Annan medicinteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering -- Other Medical Engineering (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Nyckelord
- Biopsy
- Optical
- Tumor
- Fluorescence
- Spectroscopy
- Stereotactic navigation
- 5-ALA
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas