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Sökning: onr:"swepub:oai:DiVA.org:liu-180509" > Altered resting-sta...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00007348naa a2200697 4500
001oai:DiVA.org:liu-180509
003SwePub
008211025s2021 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1805092 URI
0247 a https://doi.org/10.1038/s41398-021-01619-w2 DOI
040 a (SwePub)liu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Javaheripour, Nooshinu Jena Univ Hosp, Germany; Clin Affect Neuroimaging Lab CANLAB, Germany4 aut
2451 0a Altered resting-state functional connectome in major depressive disorder :b a mega-analysis from the PsyMRI consortium
264 c 2021-10-07
264 1b Springer Nature,c 2021
338 a electronic2 rdacarrier
500 a Funding Agencies|German Research Foundation (DFG)German Research Foundation (DFG) [KR 3822/7-1, KR 3822/7-2, FOR2107 KI588/14-1, FOR2107 KI588/14-2, FOR2107 NE2254/2-1, FOR2107 NE2254/3-1, FOR2107 DA1151/5-1, DA1151/5-2, HA7070/2-2, HA7070/3, HA7070/4]; German Research Foundation (Deutsche Forschungsgemeinschaft, DFG)German Research Foundation (DFG) [SFB779-A06]; Austrian Science Fund (FWF)Austrian Science Fund (FWF) [KLI 597-B27, KLI-148-B00, F3514-B11]; Health Research Board (HRB) Ireland; Science Foundation Ireland (SFI)Science Foundation Ireland; National Health and Medical Research CouncilNational Health and Medical Research Council of Australia [GNT1176689]; National Health and Medical Research Council of Australia (NHMRC)National Health and Medical Research Council of Australia [510135, 1037196]; German Research FoundationGerman Research Foundation (DFG) [GR 4510/2-1]; European CommissionEuropean CommissionEuropean Commission Joint Research Centre [H2020-634541]; Australian National Health and Medical Research Council of Australia (NHMRC)National Health and Medical Research Council of Australia [1064643, 1024570]; NHMRC Career Development FellowshipsNational Health and Medical Research Council of Australia [1061757, 1124472]; Interdisciplinary Center for Clinical Research (IZKF) of the medical faculty of Munster [Dan3/012/17, MzH 3/020/20]; AOP Orphan; Medizin Medien Austria; Vertretungsnetz; Schwabe Austria; JanssenJohnson & JohnsonJohnson & Johnson USAJanssen Biotech Inc; Angelini
520 a Major depressive disorder (MDD) is associated with abnormal neural circuitry. It can be measured by assessing functional connectivity (FC) at resting-state functional MRI, that may help identifying neural markers of MDD and provide further efficient diagnosis and monitor treatment outcomes. The main aim of the present study is to investigate, in an unbiased way, functional alterations in patients with MDD using a large multi-center dataset from the PsyMRI consortium including 1546 participants from 19 centers (). After applying strict exclusion criteria, the final sample consisted of 606 MDD patients (age: 35.8 +/- 11.9 y.o.; females: 60.7%) and 476 healthy participants (age: 33.3 +/- 11.0 y.o.; females: 56.7%). We found significant relative hypoconnectivity within somatosensory motor (SMN), salience (SN) networks and between SMN, SN, dorsal attention (DAN), and visual (VN) networks in MDD patients. No significant differences were detected within the default mode (DMN) and frontoparietal networks (FPN). In addition, alterations in network organization were observed in terms of significantly lower network segregation of SMN in MDD patients. Although medicated patients showed significantly lower FC within DMN, FPN, and SN than unmedicated patients, there were no differences between medicated and unmedicated groups in terms of network organization in SMN. We conclude that the network organization of cortical networks, involved in processing of sensory information, might be a more stable neuroimaging marker for MDD than previously assumed alterations in higher-order neural networks like DMN and FPN.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng
7001 a Li, Mengu Jena Univ Hosp, Germany; Clin Affect Neuroimaging Lab CANLAB, Germany4 aut
7001 a Chand, Tarau Jena Univ Hosp, Germany; Clin Affect Neuroimaging Lab CANLAB, Germany4 aut
7001 a Krug, Axelu Univ Bonn, Germany; Philipps Univ Marburg, Germany4 aut
7001 a Kircher, Tilou Philipps Univ Marburg, Germany4 aut
7001 a Dannlowski, Udou Univ Munster, Germany4 aut
7001 a Nenadic, Igoru Philipps Univ Marburg, Germany4 aut
7001 a Hamilton, Paulu Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV4 aut0 (Swepub:liu)pauha77
7001 a Sacchet, Matthew D.u Harvard Med Sch, MA USA4 aut
7001 a Gotlib, Ian H.u Stanford Univ, CA 94305 USA4 aut
7001 a Walter, Henriku Charite Univ Med Berlin, Germany; Free Univ Berlin, Germany; Berlin Inst Hlth, Germany; Humboldt Univ, Germany4 aut
7001 a Frodl, Thomasu Otto von Guericke Univ, Germany4 aut
7001 a Grimm, Simoneu Charite Univ Med Berlin, Germany4 aut
7001 a Harrison, Ben J.u Univ Melbourne, Australia4 aut
7001 a Wolf, Christian Robertu Heidelberg Univ, Germany4 aut
7001 a Olbrich, Sebastianu Dept Psychiat Psychotherapy & Psychosomat, Switzerland4 aut
7001 a van Wingen, Guidou Univ Amsterdam, Netherlands4 aut
7001 a Pezawas, Lukasu Med Univ Vienna, Austria4 aut
7001 a Parker, Gordonu Univ New South Wales, Australia4 aut
7001 a Hyett, Matthew P.u Univ Western Australia, Australia4 aut
7001 a Saemann, Philipp G.u Max Planck Inst Psychiat, Germany4 aut
7001 a Hahn, Timu Univ Munster, Germany4 aut
7001 a Steinstraeter, Olafu Philipps Univ Marburg, Germany4 aut
7001 a Jansen, Andreasu Philipps Univ Marburg, Germany; Philipps Univ Marburg, Germany4 aut
7001 a Yuksel, Dilarau SRI Int, CA USA4 aut
7001 a Kämpe, Robinu Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten4 aut0 (Swepub:liu)robka95
7001 a Davey, Christopher G.u Univ Melbourne, Australia4 aut
7001 a Meyer, Bernhardu Med Univ Vienna, Austria4 aut
7001 a Bartova, Lucieu Med Univ Vienna, Austria4 aut
7001 a Croy, Ilonau Friedrich Schiller Univ Jena, Germany; Tech Univ Dresden, Germany4 aut
7001 a Walter, Martinu Jena Univ Hosp, Germany; Clin Affect Neuroimaging Lab CANLAB, Germany; Leibniz Inst Neurobiol, Germany; Univ Tubingen, Germany4 aut
7001 a Wagner, Gerdu Jena Univ Hosp, Germany4 aut
7102 a Jena Univ Hosp, Germany; Clin Affect Neuroimaging Lab CANLAB, Germanyb Univ Bonn, Germany; Philipps Univ Marburg, Germany4 org
7730 t Translational Psychiatryd : Springer Natureg 11:1q 11:1x 2158-3188
8564 u https://liu.diva-portal.org/smash/get/diva2:1605698/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://www.nature.com/articles/s41398-021-01619-w.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-180509
8564 8u https://doi.org/10.1038/s41398-021-01619-w

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