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Role of C-tactile f...
Role of C-tactile fibers in pain modulation : animal and human perspectives
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- Larsson, Max (författare)
- Linköpings universitet,Avdelningen för neurobiologi,Medicinska fakulteten
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- Nagi, Saad (författare)
- Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten
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(creator_code:org_t)
- Elsevier, 2022
- 2022
- Engelska.
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Ingår i: Current Opinion in Behavioral Sciences. - : Elsevier. - 2352-1546. ; 43
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- C-tactile (CT) fibers, a population of unmyelinated (C) fibers that respond particularly well to gentle stroking, are widely believed to subserve affective touch. However, these fibers (termed C low-threshold mechanoreceptors (C-LTMRs) in non-human mammals) have also been proposed to be involved in the modulation of pain. Intriguingly, functional evidence from both human and animal studies indicates that CT/C-LTMR fibers can both contribute to allodynia as well as mediate pain inhibition. In the spinal cord, C-LTMR fibers form glomerular synaptic arrangements, providing input to several populations of interneurons within the nociceptive circuitry. Thus, the CT/C-LTMR system conveys signals that are subject to intricate processing in the spinal cord and is well-situated within spinal sensory pathways to enable the modulation of pain.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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