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Outcomes of Human L...
Outcomes of Human Leukocyte Antigen-Matched Allogeneic Cultivated Limbal Epithelial Transplantation in Aniridia-Associated Keratopathy-A Single-Center Retrospective Analysis
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- Behaegel, Josephine (författare)
- Univ Antwerp, Belgium; Antwerp Univ Hosp, Belgium
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- Tassignon, Marie-Jose (författare)
- Univ Antwerp, Belgium; Antwerp Univ Hosp, Belgium
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- Lagali, Neil (författare)
- Linköpings universitet,Avdelningen för sinnesorgan och kommunikation,Medicinska fakulteten,Region Östergötland, Ögonkliniken US
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- Consejo, Alejandra (författare)
- Univ Zaragoza, Spain
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- Koppen, Carina (författare)
- Univ Antwerp, Belgium; Antwerp Univ Hosp, Belgium
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- Dhubhghaill, Sorcha Ni (författare)
- Univ Antwerp, Belgium; Antwerp Univ Hosp, Belgium
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(creator_code:org_t)
- LIPPINCOTT WILLIAMS & WILKINS, 2022
- 2022
- Engelska.
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Ingår i: Cornea. - : LIPPINCOTT WILLIAMS & WILKINS. - 0277-3740 .- 1536-4798. ; 41:1, s. 69-77
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Purpose: To assess the efficacy and safety of human leukocyte antigen-matched allogeneic cultivated limbal epithelial stem cell grafts in the treatment of aniridia-associated keratopathy (AAK). Methods: Six eyes of 6 patients with severe AAK received an allogeneic stem cell graft between January 2010 and March 2017. Anatomical and functional results were assessed at 6 months, 1 year, 2 years, and the final follow-up visit available. Safety analysis was performed by considering all perioperative and postoperative adverse events and additional surgeries required during the follow-up period. Results: The mean follow-up was 53.6 months (range 24-104 months). In most patients (80%), there was an early improvement of the keratopathy postoperatively, which slowly regressed during longer follow-up. At the final follow-up, 4 of the eyes were graded as failure and 1 eye was graded as partial success. Grading the sixth eye was not possible because of an adverse event. None of the patients maintained a total anatomical success in the long-term. Only 1 patient maintained a modest improvement in best-corrected visual acuity from hand motion to counting fingers. Four serious adverse events were recorded in 2 patients. Conclusions: Severe AAK remains a challenging condition to manage. Transplantation of allogenic ex vivo cultivated limbal stem cells may provide a temporary improvement in ocular surface stability, but anatomical and functional results are poor in the long-term. The eyes are prone to adverse events, and any surgical treatment should take this into consideration.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Oftalmologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Ophthalmology (hsv//eng)
Nyckelord
- congenital aniridia; aniridia-associated keratopathy; limbal stem cell deficiency; cultivated limbal epithelial cell transplantation; HLA matching; allo-CLET
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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