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Neuropeptide Y as a...
Neuropeptide Y as a risk factor for cardiorenal disease and cognitive dysfunction in chronic kidney disease : translational opportunities and challenges
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- Zoccali, Carmine (författare)
- Renal Res Inst, NY 10027 USA; Osped Riuniti Reggio Calabria, Italy
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- Ortiz, Alberto (författare)
- Univ Leipzig, Germany
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- Blumbyte, Inga Arune (författare)
- Lithuanian Univ Hlth Sci, Lithuania
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visa fler...
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- Rudolf, Sarina (författare)
- Univ Leipzig, Germany
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- Beck-Sickinger, Annette G. (författare)
- Univ Leipzig, Germany
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- Malyszko, Jolanta (författare)
- Warsaw Med Univ, Poland
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- Spasovski, Goce (författare)
- Univ Sta Cyril & Methodius, North Macedonia
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- Carriazo, Sol (författare)
- Univ Leipzig, Germany
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- Viggiano, Davide (författare)
- Univ Campania Luigi Vanvitelli, Italy; Biogem Scarl, Italy
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- Kurganaite, Justina (författare)
- Lithuanian Univ Hlth Sci, Lithuania
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- Sarkeviciene, Vaiva (författare)
- Lithuanian Univ Hlth Sci, Lithuania
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- Rastenyte, Daiva (författare)
- Lithuanian Univ Hlth Sci, Lithuania
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- Figurek, Andreja (författare)
- Univ Zurich, Switzerland
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- Rroji, Merita (författare)
- Univ Med Tirana, Albania
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- Mayer, Christopher (författare)
- Austrian Inst Technol, Austria
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- Arici, Mustapha (författare)
- Hacettepe Univ, Turkey
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- Martino, Gianvito (författare)
- Ist Sci San Raffaele, Italy; Univ Vita Salute San Raffaele, Italy
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- Tedeschi, Gioacchino (författare)
- Univ Campania Luigi Vanvitelli, Italy; Univ Campania Luigi Vanvitelli, Italy
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- Bruchfeld, Annette (författare)
- Karolinska Institutet,Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Njurmedicinska kliniken US,CLINTEC Karolinska Inst, Sweden
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- Spoto, Belinda (författare)
- CNR IFC, Italy
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- Rychlik, Ivan (författare)
- Charles Univ Prague, Czech Republic; Fac Hosp Kralovske Vinohrady, Czech Republic
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- Wiecek, Andrzej (författare)
- Med Univ Silesia, Poland
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- Okusa, Mark (författare)
- Univ Virginia, VA USA; Univ Virginia, VA USA
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- Remuzzi, Giuseppe (författare)
- Ist Ric Farmacol Mario Negri IRCCS, Italy
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- Mallamaci, Francesca (författare)
- CNR IFC, Italy; Grande Osped Metropolitano, Italy
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(creator_code:org_t)
- 2021-12-09
- 2022
- Engelska.
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Ingår i: Nephrology, Dialysis and Transplantation. - : Oxford University Press. - 0931-0509 .- 1460-2385. ; 37, s. 14-23
- Relaterad länk:
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https://liu.diva-por... (primary) (Raw object)
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Neuropeptide Y (NPY) is a 36-amino-acid peptide member of a family also including peptide YY and pancreatic polypeptide, which are all ligands to Gi/Go coupled receptors. NPY regulates several fundamental biologic functions including appetite/satiety, sex and reproduction, learning and memory, cardiovascular and renal function and immune functions. The mesenteric circulation is a major source of NPY in the blood in man and this peptide is considered a key regulator of gut-brain cross talk. A progressive increase in circulating NPY accompanies the progression of chronic kidney disease (CKD) toward kidney failure and NPY robustly predicts cardiovascular events in this population. Furthermore, NPY is suspected as a possible player in accelerated cognitive function decline and dementia in patients with CKD and in dialysis patients. In theory, interfering with the NPY system has relevant potential for the treatment of diverse diseases from cardiovascular and renal diseases to diseases of the central nervous system. Pharmaceutical formulations for effective drug delivery and cost, as well as the complexity of diseases potentially addressable by NPY/NPY antagonists, have been a problem until now. This in part explains the slow progress of knowledge about the NPY system in the clinical arena. There is now renewed research interest in the NPY system in psychopharmacology and in pharmacology in general and new studies and a new breed of clinical trials may eventually bring the expected benefits in human health with drugs interfering with this system.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Nyckelord
- cardiovascular; CKD; dialysis; hypertension; renin-angiotensin system
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Zoccali, Carmine
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Ortiz, Alberto
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Blumbyte, Inga A ...
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Rudolf, Sarina
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Beck-Sickinger, ...
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Malyszko, Jolant ...
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visa fler...
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Spasovski, Goce
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Carriazo, Sol
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Viggiano, Davide
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Kurganaite, Just ...
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Sarkeviciene, Va ...
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Rastenyte, Daiva
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Figurek, Andreja
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Rroji, Merita
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Mayer, Christoph ...
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Arici, Mustapha
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Martino, Gianvit ...
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Tedeschi, Gioacc ...
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Bruchfeld, Annet ...
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Spoto, Belinda
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Rychlik, Ivan
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Wiecek, Andrzej
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Okusa, Mark
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Remuzzi, Giusepp ...
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Mallamaci, Franc ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Reumatologi och ...
- Artiklar i publikationen
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Nephrology, Dial ...
- Av lärosätet
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Linköpings universitet
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Karolinska Institutet