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Identification of R...
Identification of Recent Tuberculosis Exposure Using QuantiFERON-TB Gold Plus, a Multicenter Study
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- Perez-Recio, Sandra (författare)
- Bellvitge Univ Hosp, Spain
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- Pallares, Natalia (författare)
- Bellvitge Biomed Res Inst IDIBELL, Spain
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- Grijota-Camino, Maria D. (författare)
- Bellvitge Univ Hosp, Spain
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- Sanchez-Montalva, Adrian (författare)
- Vall dHebron Univ Hosp, Spain
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- Barcia, Laura (författare)
- Complexo Hosp Univ Pontevedra, Spain
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- Campos-Gutierrez, Silvia (författare)
- Univ Hosp Canary Isl, Spain
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- Pomar, Virginia (författare)
- Hosp Santa Creu & Sant Pau, Spain
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- Rabunal-Rey, Ramon (författare)
- Hosp Lucus Augusti, Spain
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- Balcells, Maria Elvira (författare)
- Pontificia Univ Catolica Chile, Chile
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- Gazel, Deniz (författare)
- Gaziantep Univ, Turkey
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- Montiel, Natalia (författare)
- Hosp Costa del Sol, Spain; Hosp Univ Puerta Mar, Spain
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- Vicente, Diego (författare)
- Hosp Univ Donostia, Spain
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- Goic-Barisic, Ivana (författare)
- Univ Hosp Split, Croatia; Univ Split, Croatia
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- Schön, Thomas, 1973- (författare)
- Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Region Östergötland, Infektionskliniken i Östergötland,Kalmar County Hospital, Kalmar,Sweden
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- Paues, Jakob (författare)
- Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Region Östergötland, Infektionskliniken i Östergötland
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- Marekovic, Ivana (författare)
- Univ Hosp Ctr Zagreb, Croatia
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- Cacho-Calvo, Juana (författare)
- Getafe Univ Hosp, Spain
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- Barac, Aleksandra (författare)
- Clin Ctr Serbia, Serbia; Univ Belgrade, Serbia
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- Goletti, Delia (författare)
- Ist Nazl Malattie Infett Lazzaro Spallanzani IRCC, Italy
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- Garcia-Gasalla, Mercedes (författare)
- Hosp Univ Son Llatzer IdISBa, Spain; Hosp Univ Son Espases IdISBa, Spain
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- Maria Barcala, Jose (författare)
- Hosp Univ Jerez, Spain
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- Teresa Tortola, Maria (författare)
- Vall dHebron Univ Hosp, Spain; Univ Autonoma Barcelona, Spain
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- Anibarro, Luis (författare)
- Complexo Hosp Univ Pontevedra, Spain
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- Suarez-Toste, Isabel (författare)
- Univ Hosp Canary Isl, Spain
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- Moga, Esther (författare)
- Hosp Santa Creu & Sant Pau, Spain
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- Gude-Gonzalez, Maria J. (författare)
- Hosp Lucus Augusti, Spain
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- Naves, Rodrigo (författare)
- Univ Chile, Chile
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- Karsligil, Tekin (författare)
- Gaziantep Univ, Turkey
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- Martin-Penaranda, Tania (författare)
- Hosp Univ Donostia, Spain
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- Stevanovic, Goran (författare)
- Clin Ctr Serbia, Serbia; Univ Belgrade, Serbia
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- Trigo, Matilde (författare)
- Complexo Hosp Univ Pontevedra, Spain
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- Rubio, Veronica (författare)
- Hosp Santa Creu & Sant Pau, Spain; Hosp Municipal Badalona, Spain
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- Karaoglan, Ilkay (författare)
- Gaziantep Univ, Turkey
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- Bayram, Nazan (författare)
- Gaziantep Univ, Turkey
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- Alcaide, Fernando (författare)
- Bellvitge Univ Hosp, Spain; Univ Barcelona, Spain
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- Tebe, Cristian (författare)
- Bellvitge Biomed Res Inst IDIBELL, Spain
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- Santin, Miguel (författare)
- Bellvitge Univ Hosp, Spain; Univ Barcelona, Spain
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(creator_code:org_t)
- American Society for Microbiology, 2021
- 2021
- Engelska.
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Ingår i: Microbiology Spectrum. - : American Society for Microbiology. - 2165-0497. ; 9:3
- Relaterad länk:
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- We investigated whether the difference of antigen tube 2 (TB2) minus antigen tube 1 (TB1) (TB22TB1) of the QuantiFERON-TB gold plus test, which has been postulated as a surrogate for the CD81 T-cell response, could be useful in identifying recent tuberculosis (TB) exposure. We looked at the interferon gamma (IFN-g) responses and differences in TB2 and TB1 tubes for 686 adults with QFT-plus positive test results. These results were compared among groups with high (368 TB contacts), low (229 patients with immune-mediated inflammatory diseases [IMID]), and indeterminate (89 asylum seekers or people from abroad [ASPFA]) risks of recent TB exposure. A TB2-TB1 value.0.6 IU.ml(-1) was deemed to indicate a true difference between tubes. In the whole cohort, 13.6%, 10.9%, and 11.2% of cases had a TB2>TB1 result in the contact, IMID, and ASPFA groups, respectively (P = 0.591). The adjusted odds ratios (aORs) for an association between a TB2-TB1 result of >0.6 IU.ml(-1) and risk of recent exposure versus contacts were 0.71 (95% confidence interval [CI], 0.31 to 1.61) for the IMID group and 0.86 (95% CI, 0.49 to 1.52) for the ASPFA group. In TB contact subgroups, 11.4%, 15.4%, and 17.7% with close, frequent, and sporadic contact had a TB2>TB1 result (P = 0.362). The aORs versus the close subgroup were 1.29 (95% CI, 0.63 to 2.62) for the frequent subgroup and 1.55 (95% CI, 0.67 to 3.60) for the sporadic subgroup. A TB2-TB1 difference of.0.6 IU.ml(-1) was not associated with increased risk of recent TB exposure, which puts into question the clinical potential as a proxy marker for recently acquired TB infection. IMPORTANCE Contact tuberculosis tracing is essential to identify recently infected people, who therefore merit preventive treatment. However, there are no diagnostic tests that can determine whether the infection is a result of a recent exposure or not. It has been suggested that by using the QuantiFERON-TB gold plus, an interferon gamma (IFN-gamma) release assay, a difference in IFN-gamma production between the two antigen tubes (TB2 minus TB1) of.0.6 IU.ml(-1) could serve as a proxy marker for recent infection. In this large multinational study, infected individuals could not be classified according to the risk of recent exposure based on differences in IFN- g in TB1 and TB2 tubes that were higher than 0.6 IU.ml(-1). QuantiFERON-TB gold plus is not able to distinguish between recent and remotely acquired tuberculosis infection, and it should not be used for that purpose in contact tuberculosis tracing.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Dermatologi och venereologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dermatology and Venereal Diseases (hsv//eng)
Nyckelord
- QuantiFERON-TB gold plus; diagnosis; latent tuberculosis infection; tuberculosis-specific CD8 T cells
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Perez-Recio, San ...
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Pallares, Natali ...
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Grijota-Camino, ...
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Sanchez-Montalva ...
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Barcia, Laura
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Campos-Gutierrez ...
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visa fler...
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Pomar, Virginia
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Rabunal-Rey, Ram ...
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Balcells, Maria ...
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Gazel, Deniz
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Montiel, Natalia
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Vicente, Diego
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Goic-Barisic, Iv ...
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Schön, Thomas, 1 ...
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Paues, Jakob
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Marekovic, Ivana
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Cacho-Calvo, Jua ...
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Barac, Aleksandr ...
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Goletti, Delia
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Garcia-Gasalla, ...
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Maria Barcala, J ...
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Teresa Tortola, ...
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Anibarro, Luis
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Suarez-Toste, Is ...
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Moga, Esther
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Gude-Gonzalez, M ...
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Naves, Rodrigo
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Karsligil, Tekin
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Martin-Penaranda ...
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Stevanovic, Gora ...
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Trigo, Matilde
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Rubio, Veronica
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Karaoglan, Ilkay
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Bayram, Nazan
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Alcaide, Fernand ...
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Tebe, Cristian
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Santin, Miguel
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Dermatologi och ...
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Microbiology Spe ...
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