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Water Flux in Cell ...
Water Flux in Cell Motility : Expanding the Mechanisms of Membrane Protrusion
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- Loitto, Vesa (författare)
- Linköpings universitet,Medicinsk mikrobiologi,Hälsouniversitetet
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- Karlsson, Thommie (författare)
- Linköpings universitet,Institutionen för klinisk och experimentell medicin,Hälsouniversitetet
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- Magnusson, Karl-Eric (författare)
- Linköpings universitet,Medicinsk mikrobiologi,Hälsouniversitetet
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(creator_code:org_t)
- Wiley, 2009
- 2009
- Engelska.
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Ingår i: CELL MOTILITY AND THE CYTOSKELETON. - : Wiley. - 0886-1544 .- 1097-0169. ; 66:5, s. 237-247
- Relaterad länk:
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https://onlinelibrar...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Transmembrane water fluxes through aquaporins (AQPs) are suggested to play, pivotal roles in cell polarization and directional cell motility. Local dilution by W water influences the dynamics of the subcortical actin polymerization and directs the formation of nascent membrane protrusions. In this paper. recent evidence is discussed in support of such a central role of AQP in membrane protrusion formation, and cell migration as a basis for our Understanding AQP9 Underlying molecular mechanisms of directional motility. Specifically. AQP9 in a physiological context controls transmembrane water fluxes driving, membrane protrusion formation, as an initial cellular response to a chemoattractant or other migratory signals. The importance of AQP-facilitated water fluxes in directional cell motility is underscored the observation that blocking or modifying specific sites in AQP9 also interferes with the molecular machinery that govern actin-mediated cellular shape changes. Cell Motil.
Nyckelord
- aquaporins
- cell motility
- polarity
- morphology
- filopodia
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
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