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Symptom burden and ...
Symptom burden and quality of life with chemotherapy for recurrent ovarian cancer : the Gynecologic Cancer InterGroup-Symptom Benefit Study
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- Lee, Yeh Chen (författare)
- Australia New Zealand Gynaecol Oncol Grp ANZGOG, Australia; Univ Sydney, Australia; Univ New South Wales, Australia
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- King, Madeleine T. (författare)
- Univ Sydney, Australia
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- OConnell, Rachel L. (författare)
- Univ Sydney, Australia
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- Lanceley, Anne (författare)
- UCL, England
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- Joly, Florence (författare)
- GINECO Grp Investigateurs Nationaux Etud Canc Ova, France; Ctr Francois Baclesse, France
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- Hilpert, Felix (författare)
- Arbeltsgesrneinschaft Gynakolog Onkol Studiengrp, Germany; North Eastern German Soc Gynecol Oncol NOGGO, Germany; Krankenhaus Jerusalem, Germany
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- Davis, Alison (författare)
- Australia New Zealand Gynaecol Oncol Grp ANZGOG, Australia; Canberra Hosp, Australia
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- Roncolato, Felicia T. (författare)
- Australia New Zealand Gynaecol Oncol Grp ANZGOG, Australia; Univ Sydney, Australia
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- Okamoto, Aikou (författare)
- Japanese Gynecol Oncol Grp JGOG, Japan; Jikei Univ, Japan
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- Bryce, Jane (författare)
- Ist Nazl Tumori IRCCS Fdn Pascale, Italy; Ascension St John Clin Res Inst, OK USA; MITO Multictr Italian Trials Ovarian & Gynecol Ca, Italy
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- Donnellan, Paul (författare)
- Galway Univ Hosp, Ireland
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- Oza, Amit M. (författare)
- Princess Margaret Consortium PMHC, Canada; Univ Toronto, Canada
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- Åvall-Lundqvist, Elisabeth, Professor, 1957- (författare)
- Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US,Nord Soc Gynaecol Oncol NSGO, Denmark; Karolinska Inst, Sweden
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- Berek, Jonathan S. (författare)
- Cooperat Gynecol Oncol Investigators COGI, CA USA; Stanford Univ, CA 94305 USA
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- Ledermann, Jonathan A. (författare)
- Canc Res UK, England; NCRI UK, England
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- Berton, Dominique (författare)
- GINECO Grp Investigateurs Nationaux Etud Canc Ova, France; Ctr Rene Gauducheau, France
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- Sehouli, Jalid (författare)
- Arbeitsgesmeinschaft Gynakol Onkol Studiengrp A, Germany; North Eastern German Soc Gynecol Oncol NOGGO, Germany; Charite Univ Med Berlin, Germany
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- Feeney, Amanda (författare)
- Canc Res UK, England; NCRI UK, England
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- Kaminsky, Marie-Christine (författare)
- GINECO Grp Investigateurs Nationaux Etud Canc Ova, France; Inst Cancerol Lorraine, France
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- Diamante, Katrina (författare)
- Univ Sydney, Australia
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- Stockler, Martin R. (författare)
- Univ Sydney, Australia
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- Friedlander, Michael L. (författare)
- Australia New Zealand Gynaecol Oncol Grp ANZGOG, Australia; Univ New South Wales, Australia
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(creator_code:org_t)
- 2022-01-27
- 2022
- Engelska.
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Ingår i: International Journal of Gynecological Cancer. - : BMJ Publishing Group. - 1048-891X .- 1525-1438. ; 32:6, s. 761-768
- Relaterad länk:
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https://liu.diva-por... (primary) (Raw object)
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https://ijgc.bmj.com...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
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- Objective The Gynecologic Cancer InterGroup (GCIG)-Symptom Benefit Study was designed to evaluate the effects of chemotherapy on symptoms and health-related quality of life (HRQL) in women having chemotherapy for platinum resistant/refractory recurrent ovarian cancer (PRR-ROC) and potentially platinum sensitive with >= 3 lines of chemotherapy (PPS-ROC >= 3). Methods Participants completed the Measure of Ovarian Cancer Symptoms and Treatment (MOST) and European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire QLQ-C30 questionnaires at baseline and every 3-4 weeks until progression. Participants were classified symptomatic if they rated >= 4 of 10 in at least one-third of symptoms in the MOST index. Improvement in MOST was defined as two consecutive scores of <= 3 in at least half of the symptomatic items at baseline. Improvement in HRQL was defined as two consecutive scores >= 10 points above baseline in the QLQ-C30 summary score scale (range 0-100). Results Of 948 participants enrolled, 910 (96%) completed baseline questionnaires: 546 with PRR-ROC and 364 with PPS-ROC >= 3. The proportions of participants symptomatic at baseline as per MOST indexes were: abdominal 54%, psychological 53%, and disease- or treatment-related 35%. Improvement was reported in MOST indexes: abdominal 40%, psychological 35%, and disease- or treatment-related 38%. Median time to improvement in abdominal symptoms occurred earlier for PRR-ROC than for PPS-ROC >= 3 (4 vs 6 weeks, p=0.044); median duration of improvement was also similar (9.0 vs 11.7 weeks, p=0.65). Progression-free survival was longer among those with improvement in abdominal symptoms than in those without (median 7.2 vs 2.5 months, p<0.0001). Improvements in HRQL were reported by 77/448 (17%) with PRR-ROC and 61/301 (20%) with PPS-ROC >= 3 (p=0.29), and 102/481 (21%) of those with abdominal symptoms at baseline. Conclusion Over 50% of participants reported abdominal and psychological symptoms at baseline. Of those, 40% reported an improvement within 2 months of starting chemotherapy. Approximately one in six participants reported an improvement in HRQL. Symptom monitoring and supportive care is important as chemotherapy palliated less than half of symptomatic participants.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Nyckelord
- ovarian cancer; quality of life (PRO); palliative care; medical oncology
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Lee, Yeh Chen
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King, Madeleine ...
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OConnell, Rachel ...
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Lanceley, Anne
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Joly, Florence
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Hilpert, Felix
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visa fler...
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Davis, Alison
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Roncolato, Felic ...
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Okamoto, Aikou
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Bryce, Jane
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Donnellan, Paul
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Oza, Amit M.
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Åvall-Lundqvist, ...
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Berek, Jonathan ...
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Ledermann, Jonat ...
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Berton, Dominiqu ...
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Sehouli, Jalid
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Feeney, Amanda
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Kaminsky, Marie- ...
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Diamante, Katrin ...
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Stockler, Martin ...
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Friedlander, Mic ...
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