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Gut Microbiota Comp...
Gut Microbiota Composition in Relation to the Metabolism of Oral Administrated Resveratrol
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- Yao, Mingfei (författare)
- Zhejiang Univ, Peoples R China
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- Fei, Yiqiu (författare)
- Zhejiang Univ, Peoples R China
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- Zhang, Shuobo (författare)
- Zhejiang Univ, Peoples R China
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- Qiu, Bo (författare)
- Zhejiang Univ, Peoples R China
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- Zhu, Lian (författare)
- Hangzhou Med Coll, Peoples R China
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- Li, Fang (författare)
- Columbia Univ, NY 10032 USA
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- Berglund, Björn (författare)
- Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten
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- Xiao, Hang (författare)
- Univ Massachusetts, MA 01003 USA
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- Li, Lanjuan (författare)
- Zhejiang Univ, Peoples R China; Jinan Microecol Biomed Shandong Lab, Peoples R China
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(creator_code:org_t)
- 2022-02-28
- 2022
- Engelska.
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Ingår i: Nutrients. - : MDPI. - 2072-6643. ; 14:5
- Relaterad länk:
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https://liu.diva-por... (primary) (Raw object)
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https://www.mdpi.com...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Resveratrol (RSV) has been confirmed to confer multiple health benefits, and the majority of RSV tends to be metabolized in the gut microbiota after oral administration. In this study, the metabolism of RSV was investigated by using mouse models with distinct gut microbiota compositions: germ-free mice colonized with probiotics, conventional mouse, and DSS-induced colitis mouse models. The results demonstrated that in feces, the metabolites of RSV, including resveratrol sulfate (RES-sulfate), resveratrol glucuronide (RES-glucuronide), and dihydroresveratrol, significantly increased after probiotics colonized in germ-free mice. Furthermore, RES-sulfate and RES-glucuronide were below the detectable limit in the feces of conventional mice, with dihydroresveratrol being the dominant metabolite. Compared to the conventional mice, the ratio of Firmicutes/Bacteroides and the abundance of Lactobacillus genera were found significantly elevated in colitis mice after long-term ingestion of RSV, which shifted the metabolism of RSV in return. Our study provided critical implications in further application of RSV in foods and food supplements.
Ämnesord
- LANTBRUKSVETENSKAPER -- Lantbruksvetenskap, skogsbruk och fiske -- Livsmedelsvetenskap (hsv//swe)
- AGRICULTURAL SCIENCES -- Agriculture, Forestry and Fisheries -- Food Science (hsv//eng)
Nyckelord
- resveratrol (RSV); metabolites; gut microbiota; mouse model; Ligilactobacillus salivarious Li01
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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