Sökning: onr:"swepub:oai:DiVA.org:liu-184128" >
Alterations of Stre...
-
Voegel, Clarissa D.Univ Zurich, Switzerland
(författare)
Alterations of Stress-Related Glucocorticoids and Endocannabinoids in Hair of Chronic Cocaine Users
- Artikel/kapitelEngelska2022
Förlag, utgivningsår, omfång ...
-
2021-10-22
-
Oxford University Press,2022
-
electronicrdacarrier
Nummerbeteckningar
-
LIBRIS-ID:oai:DiVA.org:liu-184128
-
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-184128URI
-
https://doi.org/10.1093/ijnp/pyab070DOI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
Funding Agencies|Forschungskredit of the University of Zurich [FK-20-041]; Swiss National Science Foundation (SNSF)Swiss National Science Foundation (SNSF) [PP00P1-123516/1, PP00P1-146326/1]; Olga Mayenfisch Foundation
-
Background Previous research in animals and humans has demonstrated a potential role of stress regulatory systems, such as the hypothalamic-pituitary-adrenal (HPA) axis and the endocannabinoid (eCB) system, in the development of substance use disorders. We thus investigated alterations of HPA and eCB markers in individuals with chronic cocaine use disorder by using an advanced hair analysis technique. Methods We compared hair concentrations of glucocorticoids (cortisone, cortisol) and the eCBs 2-arachidonylglycerol, anandamide (AEA), oleoylethanolamide (OEA), and palmitoylethanolamide (PEA) between 48 recreational cocaine users (RCU), 25 dependent cocaine users (DCU), and 67 stimulant-naive controls. Self-reported substance use and hair concentrations of substances were also assessed. Results Significantly higher concentrations of hair cortisone were found in RCU and DCU compared with controls. Hair concentrations of OEA and PEA were significantly lower in DCU compared with RCU and controls. Additionally, within cocaine users, elevated cocaine hair concentration was a significant predictor for increased glucocorticoid and decreased OEA hair levels. Moreover, higher 3,4-methyl enedioxymethamphetamine hair concentration was correlated with elevated cortisone and AEA, OEA, and PEA levels in hair within cocaine users, whereas more self-reported cannabis use was associated with lower eCBs levels in hair across the total sample. Conclusion Our findings support the hypothesis that the HPA axis and eCB system might be important regulators for substance use disorders. The mechanistic understanding of changes in glucocorticoid and eCB levels in future research might be a promising pharmacological target to reduce stress-induced craving and relapse specifically in cocaine use disorder.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Kroll, SaraLinköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten,Univ Zurich, Switzerland(Swepub:liu)sarkr94
(författare)
-
Schmid, Marc W.MWSchmid GmbH, Switzerland
(författare)
-
Kexel, Ann-KathrinUniv Zurich, Switzerland
(författare)
-
Baumgartner, Markus R.Univ Zurich, Switzerland
(författare)
-
Kraemer, ThomasUniv Zurich, Switzerland
(författare)
-
Binz, Tina M.Univ Zurich, Switzerland
(författare)
-
Quednow, Boris B.Univ Zurich, Switzerland; Univ Zurich, Switzerland; Swiss Fed Inst Technol, Switzerland
(författare)
-
Univ Zurich, SwitzerlandCentrum för social och affektiv neurovetenskap
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:International Journal of Neuropsychopharmacology: Oxford University Press25:3, s. 226-2371461-14571469-5111
Internetlänk
Hitta via bibliotek
Till lärosätets databas