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Identification of L...
Identification of LINE retrotransposons and long non-coding RNAs expressed in the octopus brain
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- Petrosino, Giuseppe (författare)
- Stazione Zool Anton Dohrn, Italy; Inst Mol Biol IMB, Germany
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- Ponte, Giovanna (författare)
- Stazione Zool Anton Dohrn, Italy
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- Volpe, Massimiliano (författare)
- Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten,Stazione Zool Anton Dohrn, Italy; Ist Italiano Tecnol IIT, Italy
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- Zarrella, Ilaria (författare)
- Stazione Zool Anton Dohrn, Italy
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- Ansaloni, Federico (författare)
- Ist Italiano Tecnol IIT, Italy
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- Langella, Concetta (författare)
- Stazione Zool Anton Dohrn, Italy
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- Di Cristina, Giulia (författare)
- Stazione Zool Anton Dohrn, Italy; Univ Cologne, Germany
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- Finaurini, Sara (författare)
- Scuola Int Super Avanzati SISSA, Italy
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- Russo, Monia T. (författare)
- Stazione Zool Anton Dohrn, Italy
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- Basu, Swaraj (författare)
- Stazione Zool Anton Dohrn, Italy; Strand Life Sci, India
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- Musacchia, Francesco (författare)
- Stazione Zool Anton Dohrn, Italy
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- Ristoratore, Filomena (författare)
- Stazione Zool Anton Dohrn, Italy
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- Pavlinic, Dinko (författare)
- European Mol Biol Lab EMBL, Germany; Inst Mol & Clin Ophthalmol, Switzerland
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- Benes, Vladimir (författare)
- European Mol Biol Lab EMBL, Germany
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- Ferrante, Maria I. (författare)
- Stazione Zool Anton Dohrn, Italy
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- Albertin, Caroline (författare)
- Marine Biol Lab MBL, MA USA
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- Simakov, Oleg (författare)
- Grad Univ, Japan; Univ Wien, Austria
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- Gustincich, Stefano (författare)
- Ist Italiano Tecnol IIT, Italy; Scuola Int Super Avanzati SISSA, Italy
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- Fiorito, Graziano (författare)
- Stazione Zool Anton Dohrn, Italy
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- Sanges, Remo (författare)
- Stazione Zool Anton Dohrn, Italy; Ist Italiano Tecnol IIT, Italy; Scuola Int Super Avanzati SISSA, Italy
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(creator_code:org_t)
- 2022-05-18
- 2022
- Engelska.
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Ingår i: BMC Biology. - : BMC. - 1741-7007. ; 20:1
- Relaterad länk:
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background Transposable elements (TEs) widely contribute to the evolution of genomes allowing genomic innovations, generating germinal and somatic heterogeneity, and giving birth to long non-coding RNAs (lncRNAs). These features have been associated to the evolution, functioning, and complexity of the nervous system at such a level that somatic retrotransposition of long interspersed element (LINE) L1 has been proposed to be associated to human cognition. Among invertebrates, octopuses are fascinating animals whose nervous system reaches a high level of complexity achieving sophisticated cognitive abilities. The sequencing of the genome of the Octopus bimaculoides revealed a striking expansion of TEs which were proposed to have contributed to the evolution of its complex nervous system. We recently found a similar expansion also in the genome of Octopus vulgaris. However, a specific search for the existence and the transcription of full-length transpositionally competent TEs has not been performed in this genus. Results Here, we report the identification of LINE elements competent for retrotransposition in Octopus vulgaris and Octopus bimaculoides and show evidence suggesting that they might be transcribed and determine germline and somatic polymorphisms especially in the brain. Transcription and translation measured for one of these elements resulted in specific signals in neurons belonging to areas associated with behavioral plasticity. We also report the transcription of thousands of lncRNAs and the pervasive inclusion of TE fragments in the transcriptomes of both Octopus species, further testifying the crucial activity of TEs in the evolution of the octopus genomes. Conclusions The neural transcriptome of the octopus shows the transcription of thousands of putative lncRNAs and of a full-length LINE element belonging to the RTE class. We speculate that a convergent evolutionary process involving retrotransposons activity in the brain has been important for the evolution of sophisticated cognitive abilities in this genus.
Ämnesord
- NATURVETENSKAP -- Biologi -- Annan biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Other Biological Topics (hsv//eng)
Nyckelord
- Mollusks; Nervous system; Transcriptome; Transposable elements
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Petrosino, Giuse ...
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Ponte, Giovanna
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Volpe, Massimili ...
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Zarrella, Ilaria
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Ansaloni, Federi ...
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Langella, Concet ...
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Di Cristina, Giu ...
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Finaurini, Sara
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Russo, Monia T.
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Basu, Swaraj
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Musacchia, Franc ...
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Ristoratore, Fil ...
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Pavlinic, Dinko
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Benes, Vladimir
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Ferrante, Maria ...
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Albertin, Caroli ...
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Simakov, Oleg
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Gustincich, Stef ...
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Fiorito, Grazian ...
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Sanges, Remo
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- Om ämnet
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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och Annan biologi
- Artiklar i publikationen
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BMC Biology
- Av lärosätet
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Linköpings universitet