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Sortilin Modulates ...
Sortilin Modulates Schwann Cell Signaling and Remak Bundle Regeneration Following Nerve Injury
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- Ulrichsen, Maj (författare)
- Aarhus Univ, Denmark
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- Goncalves, Nadia P. (författare)
- Aarhus Univ, Denmark
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- Mohseni, Simin (författare)
- Linköpings universitet,Avdelningen för neurobiologi,Medicinska fakulteten
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- Hjaeresen, Simone (författare)
- Univ Southern Denmark, Denmark
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- Lisle, Thomas L. (författare)
- Aarhus Univ, Denmark
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- Molgaard, Simon (författare)
- Aarhus Univ, Denmark
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- Madsen, Niels K. (författare)
- Aarhus Univ, Denmark
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- Andersen, Olav M. (författare)
- Aarhus Univ, Denmark
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- Svenningsen, Åsa F. (författare)
- Univ Southern Denmark, Denmark
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- Glerup, Simon (författare)
- Aarhus Univ, Denmark
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- Nykjaer, Anders (författare)
- Aarhus Univ, Denmark; Aarhus Univ Hosp, Denmark; Aarhus Univ, Denmark
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- Vaegter, Christian B. (författare)
- Aarhus Univ, Denmark
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(creator_code:org_t)
- 2022-05-11
- 2022
- Engelska.
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Ingår i: Frontiers in Cellular Neuroscience. - : Frontiers Media SA. - 1662-5102. ; 16
- Relaterad länk:
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Peripheral nerve regeneration relies on the ability of Schwann cells to support the regrowth of damaged axons. Schwann cells re-differentiate when reestablishing contact with the sprouting axons, with large fibers becoming remyelinated and small nociceptive fibers ensheathed and collected into Remak bundles. We have previously described how the receptor sortilin facilitates neurotrophin signaling in peripheral neurons via regulated trafficking of Trk receptors. This study aims to characterize the effects of sortilin deletion on nerve regeneration following sciatic crush injury. We found that Sort1(-)(/)(-) mice displayed functional motor recovery like that of WT mice, with no detectable differences in relation to nerve conduction velocities and morphological aspects of myelinated fibers. In contrast, we found abnormal ensheathment of regenerated C-fibers in injured Sort1(-)(/)(-) mice, demonstrating a role of sortilin for Remak bundle formation following injury. Further studies on Schwann cell signaling pathways showed a significant reduction of MAPK/ERK, RSK, and CREB phosphorylation in Sort1(-)(/)(-) Schwann cells after stimulation with neurotrophin-3 (NT-3), while Schwann cell migration and myelination remained unaffected. In conclusion, our results demonstrate that loss of sortilin blunts NT-3 signaling in Schwann cells which might contribute to the impaired Remak bundle regeneration after sciatic nerve injury.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- nerve injury; NT-3; TrkC; sortilin; Schwann cell; Remak bundle
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Ulrichsen, Maj
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Goncalves, Nadia ...
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Mohseni, Simin
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Hjaeresen, Simon ...
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Lisle, Thomas L.
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Molgaard, Simon
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visa fler...
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Madsen, Niels K.
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Andersen, Olav M ...
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Svenningsen, Åsa ...
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Glerup, Simon
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Nykjaer, Anders
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Vaegter, Christi ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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och Medicinska och f ...
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och Neurovetenskaper
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Frontiers in Cel ...
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Linköpings universitet