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Parental TB associa...
Parental TB associated with offspring asthma and rhinitis
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- Lopez-Cervantes, J. P. (författare)
- Univ Bergen, Norway; Haukeland Hosp, Norway
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- Shigdel, R. (författare)
- Univ Bergen, Norway
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- Accordini, S. (författare)
- Univ Verona, Italy
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- Mustafa, T. (författare)
- Univ Bergen, Norway
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- Bertelsen, R. J. (författare)
- Univ Bergen, Norway
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- Makvandi-Nejad, S. (författare)
- Univ Bergen, Norway; Haukeland Hosp, Norway
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- Lerm, Maria, Professor, 1973- (författare)
- Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten
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- Horsnell, W. (författare)
- Univ Cape Town, South Africa; Univ Birmingham, England
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- Svanes, C. (författare)
- Univ Bergen, Norway; Haukeland Hosp, Norway
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(creator_code:org_t)
- Paris, France : International Union Against Tuberculosis and Lung Disease, 2022
- 2022
- Engelska.
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Ingår i: The International Journal of Tuberculosis and Lung Disease. - Paris, France : International Union Against Tuberculosis and Lung Disease. - 1027-3719 .- 1815-7920. ; 26:6, s. 544-549
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.5...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Infections in early life are associated with asthma and allergies in one-generation settings; however, the link between parental infection and offspring phenotype is rarely investigated. We aim to study the association of parental TB before conception of the offspring with offspring asthma and rhinitis.METHODS: We included 2,965 offspring born in 1985- 2004 and registered in the Norwegian prescription database to 1,790 parents born after 1960 with a history of TB, and included in the Norwegian TB registry. Offspring asthma (n = 582) and rhinitis (n = 929) were defined based on diagnosis, type of medication and prescribed medication >1 year. Associations of parental TB ,8 years, >8 years but before offsprings birth year and after birth (reference category) with offspring asthma and rhinitis were analysed using logistic regression.RESULTS: Asthma risk was higher in persons with parental TB in childhood (OR 1.73, 95% CI 1.20- 2.50) or later preconception (OR 1.38, 95% CI 1.00- 1.91) than in persons with parental TB after offsprings birth; this was significant only in the maternal line (childhood: OR 1.95, 95% CI 1.13-3.37; later precon-ception: OR 1.74, 95% CI 1.08-2.80). Associations with rhinitis were not identified.CONCLUSIONS: Parental childhood TB was associated with higher asthma risk in future offspring. We speculate that TB impacts maternal immunity , dysregulates the offsprings type 2 immunity , that TB-induced epigenetic reprograming of immune defences are trans-ferred to the offspring.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Nyckelord
- infections; preconception; intergenera-tional; NCDs
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Lopez-Cervantes, ...
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Shigdel, R.
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Accordini, S.
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Mustafa, T.
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Bertelsen, R. J.
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Makvandi-Nejad, ...
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visa fler...
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Lerm, Maria, Pro ...
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Horsnell, W.
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Svanes, C.
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Linköpings universitet