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Multiscale optical ...
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Ni, RuiqingUniv Zurich, Switzerland; Swiss Fed Inst Technol, Switzerland; Univ Zurich, Switzerland; Univ Zurich, Switzerland
(författare)
Multiscale optical and optoacoustic imaging of amyloid-beta deposits in mice
- Artikel/kapitelEngelska2022
Förlag, utgivningsår, omfång ...
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2022-07-14
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NATURE PORTFOLIO,2022
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:liu-187387
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-187387URI
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https://doi.org/10.1038/s41551-022-00906-1DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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Funding Agencies|European Research Council [ERC-2015-CoG-682379]; US National Institutes of Health [UF1-NS107680]; Swiss National Science Foundation [310030_192757]; Swedish Research Council [2016-00748]; Nomis Distinguished Scientist Award. J.K. received funding from the Swiss National Science Foundation [320030_179277, 32NE30_173678/1]; Synapsis foundation; Vontobel foundation; Synapsis foundation career development award [2017 CDA-03]; UZH Innovation [MEDEF20-021]; Helmut Horten Stiftung; Vontobel Stiftung; Jubilaumsstiftung von Swiss Life; European Union [746430]
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Large-field multifocal illumination fluorescence microscopy and panoramic volumetric multispectral optoacoustic tomography can be combined to longitudinally assess amyloid-beta deposits in transgenic mouse models of Alzheimers disease. Deposits of amyloid-beta (A beta) in the brains of rodents can be analysed by invasive intravital microscopy on a submillimetre scale, or via whole-brain images from modalities lacking the resolution or molecular specificity to accurately characterize A beta pathologies. Here we show that large-field multifocal illumination fluorescence microscopy and panoramic volumetric multispectral optoacoustic tomography can be combined to longitudinally assess A beta deposits in transgenic mouse models of Alzheimers disease. We used fluorescent A beta-targeted probes (the luminescent conjugated oligothiophene HS-169 and the oxazine-derivative AOI987) to transcranially detect A beta deposits in the cortex of APP/PS1 and arcA beta mice with single-plaque resolution (8 mu m) and across the whole brain (including the hippocampus and the thalamus, which are inaccessible by conventional intravital microscopy) at sub-150 mu m resolutions. Two-photon microscopy, light-sheet microscopy and immunohistochemistry of brain-tissue sections confirmed the specificity and regional distributions of the deposits. High-resolution multiscale optical and optoacoustic imaging of A beta deposits across the entire brain in rodents thus facilitates the in vivo study of A beta accumulation by brain region and by animal age and strain.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Chen, ZhenyueUniv Zurich, Switzerland; Swiss Fed Inst Technol, Switzerland; Univ Zurich, Switzerland
(författare)
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Dean-Ben, Xose LuisUniv Zurich, Switzerland; Swiss Fed Inst Technol, Switzerland; Univ Zurich, Switzerland
(författare)
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Voigt, Fabian F.Swiss Fed Inst Technol, Switzerland; Univ Zurich, Switzerland; Univ Zurich, Switzerland
(författare)
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Kirschenbaum, DanielUniv Spital Zurich, Switzerland
(författare)
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Shi, GloriaUniv Zurich, Switzerland; Swiss Fed Inst Technol, Switzerland
(författare)
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Villois, AlessiaSwiss Fed Inst Technol, Switzerland
(författare)
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Zhou, QuanyuUniv Zurich, Switzerland; Swiss Fed Inst Technol, Switzerland; Univ Zurich, Switzerland
(författare)
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Crimi, AlessandroUniv Spital Zurich, Switzerland
(författare)
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Arosio, PaoloSwiss Fed Inst Technol, Switzerland
(författare)
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Nitsch, Roger M.Swiss Fed Inst Technol, Switzerland; Univ Zurich, Switzerland; Univ Zurich, Switzerland
(författare)
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Nilsson, Peter,1970-Linköpings universitet,Kemi,Tekniska fakulteten(Swepub:liu)petni61
(författare)
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Aguzzi, AdrianoSwiss Fed Inst Technol, Switzerland; Univ Zurich, Switzerland; Univ Spital Zurich, Switzerland
(författare)
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Helmchen, FritjofSwiss Fed Inst Technol, Switzerland; Univ Zurich, Switzerland; Univ Zurich, Switzerland
(författare)
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Klohs, JanUniv Zurich, Switzerland; Swiss Fed Inst Technol, Switzerland; Univ Zurich, Switzerland
(författare)
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Razansky, DanielUniv Zurich, Switzerland; Swiss Fed Inst Technol, Switzerland; Univ Zurich, Switzerland; Univ Zurich, Switzerland
(författare)
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Univ Zurich, Switzerland; Swiss Fed Inst Technol, Switzerland; Univ Zurich, Switzerland; Univ Zurich, SwitzerlandUniv Zurich, Switzerland; Swiss Fed Inst Technol, Switzerland; Univ Zurich, Switzerland
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Nature Biomedical Engineering: NATURE PORTFOLIO6, s. 1031-10442157-846X
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Ni, Ruiqing
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Chen, Zhenyue
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Dean-Ben, Xose L ...
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Voigt, Fabian F.
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Kirschenbaum, Da ...
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Shi, Gloria
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visa fler...
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Villois, Alessia
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Zhou, Quanyu
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Crimi, Alessandr ...
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Arosio, Paolo
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Nitsch, Roger M.
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Nilsson, Peter, ...
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Aguzzi, Adriano
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Helmchen, Fritjo ...
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Klohs, Jan
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Razansky, Daniel
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