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Factors Associated ...
Factors Associated With the Decay of Anti-SARS-CoV-2 S1 IgG Antibodies Among Recipients of an Adenoviral Vector-Based AZD1222 and a Whole-Virion Inactivated BBV152 Vaccine
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- Selvavinayagam, Sivaprakasam T. (författare)
- State Publ Hlth Lab, India
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- Yong, Yean Kong (författare)
- Xiamen Univ Malaysia, Malaysia
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- Tan, Hong Yien (författare)
- Xiamen Univ Malaysia, Malaysia
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- Zhang, Ying (författare)
- Xiamen Univ Malaysia, Malaysia
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- Subramanian, Gurunathan (författare)
- State Publ Hlth Lab, India
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- Rajeshkumar, Manivannan (författare)
- State Publ Hlth Lab, India
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- Vasudevan, Kalaivani (författare)
- State Publ Hlth Lab, India
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- Jayapal, Priyanka (författare)
- State Publ Hlth Lab, India
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- Narayanasamy, Krishnasamy (författare)
- Govt Corona Hosp, India
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- Ramesh, Dinesh (författare)
- State Publ Hlth Lab, India
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- Palani, Sampath (författare)
- State Publ Hlth Lab, India
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- Larsson, Marie (författare)
- Linköpings universitet,Avdelningen för molekylär medicin och virologi,Medicinska fakulteten
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- Shankar, Esaki M. (författare)
- Cent Univ Tamil Nadu, India
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- Raju, Sivadoss (författare)
- State Publ Hlth Lab, India
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(creator_code:org_t)
- 2022-06-13
- 2022
- Engelska.
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Ingår i: Frontiers in Medicine. - : Frontiers Media SA. - 2296-858X. ; 9
- Relaterad länk:
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- BackgroundThe magnitude of protection conferred following recovery from COVID-19 or by vaccine administration, and the duration of protective immunity developed, remains ambiguous. MethodsWe investigated the factors associated with anti-SARS-CoV-2 S1 IgG decay in 519 individuals who recovered from COVID-19 illness or received COVID-19 vaccination with two commercial vaccines, viz., an adenoviral vector-based (AZD1222) and a whole-virion-based inactivated (BBV152) vaccine in Chennai, India from March to December 2021. Blood samples collected during regular follow-up post-infection/-vaccination were examined for anti-SARS-CoV-2 S1 IgG by a commercial automated chemiluminescent immunoassay (CLIA). ResultsAge and underlying comorbidities were the two variables that were independently associated with the development of a breakthrough infection. Individuals who were >60 years of age with underlying comorbid conditions (viz., hypertension, diabetes mellitus and cardiovascular disease) had a ~15 times and ~10 times greater odds for developing a breakthrough infection and hospitalization, respectively. The time elapsed since the first booster dose was associated with attrition in anti-SARS-CoV-2 IgG, where each month passed was associated with an ebb in the anti-SARS-CoV-2 IgG antibody levels by a coefficient of -6 units. ConclusionsOur findings advocate that the elderly with underlying comorbidities be administered with appropriate number of booster doses with AZD1222 and BBV152 against COVID-19.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Nyckelord
- AZD1222; BBV152; COVID-19; IgG decay; SARS-CoV-2; vaccination
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Selvavinayagam, ...
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Yong, Yean Kong
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Tan, Hong Yien
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Zhang, Ying
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Subramanian, Gur ...
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Rajeshkumar, Man ...
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Vasudevan, Kalai ...
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Jayapal, Priyank ...
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Narayanasamy, Kr ...
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Ramesh, Dinesh
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Palani, Sampath
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Larsson, Marie
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Shankar, Esaki M ...
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Raju, Sivadoss
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- MEDICIN OCH HÄLSOVETENSKAP
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Frontiers in Med ...
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