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Fluid REStriction i...
Fluid REStriction in Heart Failure vs Liberal Fluid UPtake : Rationale and Design of the Randomized FRESH-UP Study
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- Herrmann, Job J. (författare)
- Radboud Univ Nijmegen, Netherlands
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- Beckers-Wesche, Fabienne (författare)
- Maastricht Univ, Netherlands
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- Baltussen, Lisette E. H. J. M. (författare)
- Radboud Univ Nijmegen, Netherlands
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- Verdijk, Marjolein H. I (författare)
- Radboud Univ Nijmegen, Netherlands
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- Bellersen, Louise (författare)
- Radboud Univ Nijmegen, Netherlands
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- Brunner-la Rocca, Hans-Peter (författare)
- Maastricht Univ, Netherlands
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- Jaarsma, Tiny (författare)
- Linköpings universitet,Avdelningen för omvårdnad och reproduktiv hälsa,Medicinska fakulteten
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- Pisters, Ron (författare)
- Rijnstate Hosp, Netherlands
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- Sanders-van Wijk, Sandra (författare)
- Zuyderland Med Ctr, Netherlands
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- Rodwell, Laura (författare)
- Radboud Univ Nijmegen, Netherlands
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- Van Royen, Niels (författare)
- Radboud Univ Nijmegen, Netherlands
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- Gommans, D. H. Frank (författare)
- Radboud Univ Nijmegen, Netherlands
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- Van Kimmenade, Roland R. J. (författare)
- Radboud Univ Nijmegen, Netherlands
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(creator_code:org_t)
- Churchill Livingstone, 2022
- 2022
- Engelska.
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Ingår i: Journal of Cardiac Failure. - : Churchill Livingstone. - 1071-9164 .- 1532-8414. ; 28:10, s. 1522-1530
- Relaterad länk:
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Aims: It is common practice for clinicians to advise fluid restriction in patients with heart failure (HF), but data from clinical trials are lacking. Moreover, fluid restriction is associated with thirst distress and may adversely impact quality of life (QoL). To address this gap in evidence, the Fluid REStriction in Heart failure vs liberal fluid UPtake (FRESH-UP) study was initiated. Methods: The FRESH-UP study is a randomized, controlled, open-label, multicenter trial to investigate the effects of a 3-month period of liberal fluid intake vs fluid restriction (1500 mL/day) on QoL in outpatients with chronic HF (New York Heart Association Classes II-III). The primary aim is to assess the effect on QoL after 3 months using the Overall Summary Score of the Kansas City Cardiomyopathy Questionnaire (KCCQ). Thirst distress, as assessed by the Thirst Distress Scale for patients with HF, KCCQ Clinical Summary Score, each of the KCCQ domains and clinically meaningful changes in these scores, the EQ-5D-5L, patient-reported fluid intake and safety (ie, death, HF hospitalizations) are secondary outcomes. The FRESH-UP study is registered at ClinicalTrials.gov (NCT04551729). Conclusion: The results of the FRESH-UP study will add substantially to the level of evidence concerning fluid management in chronic HF and may impact the QoL of these patients.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Chronic heart failure; Fluid restriction; Liberal fl uid intake; Quality of life
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Herrmann, Job J.
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Beckers-Wesche, ...
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Baltussen, Liset ...
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Verdijk, Marjole ...
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Bellersen, Louis ...
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Brunner-la Rocca ...
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visa fler...
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Jaarsma, Tiny
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Pisters, Ron
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Sanders-van Wijk ...
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Rodwell, Laura
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Van Royen, Niels
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Gommans, D. H. F ...
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Van Kimmenade, R ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
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Journal of Cardi ...
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Linköpings universitet