Sökning: onr:"swepub:oai:DiVA.org:liu-191384" >
Predictors of hypog...
Predictors of hypogammaglobulinemia in ANCA-associated vasculitis after a rituximab-based induction: a multicentre study
-
- Podesta, Manuel Alfredo (författare)
- Univ Milan, Italy; Harvard Med Sch, MA 02115 USA,University of Milan
-
- Mescia, Federica (författare)
- ASST Spedali Civili, Italy; ASST Spedali Civili, Italy; Univ Brescia, Italy,University of Brescia
-
- Ricchiuto, Anna (författare)
- Univ Milan, Italy,University of Milan
-
visa fler...
-
- Smith, Rona (författare)
- Univ Cambridge, England,University of Cambridge
-
- Tedesco, Martina (författare)
- ASST Spedali Civili, Italy; ASST Spedali Civili, Italy; Univ Brescia, Italy,University of Brescia
-
- Cassia, Matthias Arnaldo (författare)
- Univ Milan, Italy,University of Milan
-
- Holle, Julia (författare)
- Rheumazentrum Schleswig Holstein Mitte, Germany
-
- Sinico, Renato Alberto (författare)
- Univ Milano Bicocca, Italy; ASST Monza, Italy,University of Milano-Bicocca
-
- Bruchfeld, Annette (författare)
- Linköping University,Karolinska Institutet,Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Njurmedicinska kliniken US,Karolinska Inst, Sweden
-
- Gunnarsson, Iva (författare)
- Karolinska Institutet,Karolinska Univ Hosp, Sweden,Karolinska University Hospital
-
- Ohlsson, Sophie (författare)
- Lund University,Lunds universitet,Autoimmunitet och njursjukdomar,Forskargrupper vid Lunds universitet,Autoimmunity and kidney diseases,Lund University Research Groups
-
- Baslund, Bo (författare)
- Copenhagen Univ Hosp, Denmark
-
- Hruskova, Zdenka (författare)
- Charles Univ Prague, Czech Republic
-
- Tesar, Vladimir (författare)
- Charles Univ Prague, Czech Republic
-
- Sabiu, Gianmarco (författare)
- Univ Milan, Italy; ASST Fatebenefratelli Sacco, Italy
-
- Gallieni, Maurizio (författare)
- Univ Milan, Italy; ASST Fatebenefratelli Sacco, Italy
-
- Cid, Maria C. (författare)
- Univ Barcelona, Spain,Univ Milan, Italy
-
- Vaglio, Augusto (författare)
- Univ Firenze, Italy; Meyer Childrens Hosp, Italy
-
- Harper, Lorraine (författare)
- Univ Birmingham, England
-
- Cozzolino, Mario (författare)
- Univ Milan, Italy
-
- Scolari, Francesco (författare)
- ASST Spedali Civili, Italy; ASST Spedali Civili, Italy; Univ Brescia, Italy
-
- Jayne, David (författare)
- Univ Cambridge, England
-
- Alberici, Federico (författare)
- ASST Spedali Civili, Italy; ASST Spedali Civili, Italy; Univ Brescia, Italy
-
visa färre...
-
(creator_code:org_t)
- 2022-12-23
- 2023
- Engelska.
-
Ingår i: Rheumatology. - : OXFORD UNIV PRESS. - 1462-0324 .- 1462-0332. ; 62:8, s. 2850-2854
- Relaterad länk:
-
http://dx.doi.org/10...
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
http://kipublication...
-
https://lup.lub.lu.s...
-
visa färre...
Abstract
Ämnesord
Stäng
- Objectives Rituximab has become the cornerstone of induction treatment in ANCA-associated vasculitis (AAV). B-cell depletion may increase the risk of hypogammaglobulinemia, potentially leading to severe infections. This study aims to assess factors associated with hypogammaglobulinemia in AAV patients treated with rituximab. Methods This retrospective cohort study included AAV patients treated with rituximab induction in 14 European centres. Severe adverse events (SAEs) were defined as episodes requiring hospitalization or intravenous antibiotics, malignancies, or death. Linear and logistic regression were used to identify predictors of IgG levels and of the risk of hypogammaglobulinemia, defined as IgG <= 7 g/l at 6 months. Results The study included 227 patients. IgG levels at 6 months were lower than baseline (P < 0.001). Patients requiring intravenous antibiotics during the first 6 months had lower IgG levels at 6 months (P = 0.004). Age [beta (95% CI): -0.23 (-0.38, -0.08) per 10 years, P = 0.003], oral glucocorticoid dose at induction [beta (95% CI): -0.37 (-0.51, -0.24) per sqrt-transformed mg prednisone, P < 0.001] and concomitant use of intravenous glucocorticoid pulses [beta (95% CI): -0.88 (-1.73, -0.02), P = 0.044] were associated with IgG levels at 6 months. Hypogammaglobulinemia was identified in 97 (42.7%) patients. In multivariable logistic regression, factors associated with the risk of hypogammaglobulinemia were age [OR (95% CI): 1.46 (1.15, 1.86) per 10 years, P = 0.002] and oral glucocorticoid dose at induction [OR (95% CI): 1.52 (1.23, 1.89) per 10 mg prednisone, P < 0.001]. Conclusions In AAV patients treated with rituximab, hypogammaglobulinemia at 6 months after induction is common, and lower IgG levels are associated with serious infections. The risk of hypogammaglobulinemia in these patients increases with age and higher glucocorticoid doses.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Nyckelord
- ANCA-associated vasculitis; rituximab; glucocorticoids; immunosuppression; cyclophosphamide; immunoglobulins; hypogammaglobulinemia; severe adverse events; severe infections; retrospective study
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Podesta, Manuel ...
-
Mescia, Federica
-
Ricchiuto, Anna
-
Smith, Rona
-
Tedesco, Martina
-
Cassia, Matthias ...
-
visa fler...
-
Holle, Julia
-
Sinico, Renato A ...
-
Bruchfeld, Annet ...
-
Gunnarsson, Iva
-
Ohlsson, Sophie
-
Baslund, Bo
-
Hruskova, Zdenka
-
Tesar, Vladimir
-
Sabiu, Gianmarco
-
Gallieni, Mauriz ...
-
Cid, Maria C.
-
Vaglio, Augusto
-
Harper, Lorraine
-
Cozzolino, Mario
-
Scolari, Frances ...
-
Jayne, David
-
Alberici, Federi ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Reumatologi och ...
- Artiklar i publikationen
-
Rheumatology
- Av lärosätet
-
Linköpings universitet
-
Karolinska Institutet
-
Lunds universitet