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Extracellular vesic...
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Padilla, LorenaUniv Girona, Spain; Univ Murcia, Spain
(författare)
Extracellular vesicles would be involved in the release and delivery of seminal TGF-beta isoforms in pigs
- Artikel/kapitelEngelska2023
Förlag, utgivningsår, omfång ...
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2023-02-10
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FRONTIERS MEDIA SA,2023
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:liu-192509
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-192509URI
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https://doi.org/10.3389/fvets.2023.1102049DOI
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Språk:engelska
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Sammanfattning på:engelska
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Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Funding Agencies|Spanish Ministry of Science and Innovation - MCIN/AEI , Madrid, Spain [PID2020-113493RB-I00]; European Union [891382]; FORMAS, Stockholm [2019-00288]
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Introduction : Pig seminal plasma (SP) is rich in active forms of all three isoforms (1-3) of transforming growth factor beta (TGF-beta), a chemokine modulatory of the immune environment in the female genital tract once semen is delivered during mating or artificial insemination (AI). The present study aimed to examine how TGF-beta s are secreted by the epithelium of the male reproductive tract and how they are transported in semen, emphasizing the interplay with seminal extracellular vesicles (sEVs). Methods : Source of TGF-beta s was examined by immunohistochemistry in testis, epididymis, and accessory sex glands, by immunocytochemistry in ejaculated spermatozoa, and by Luminex xMAP((R)) technology in SP and sEVs retrieved from healthy, fertile male pigs used as breeders in AI programs. Results : All three TGF-beta isoforms were expressed in all reproductive tissues explored and would be released into ductal lumen either in soluble form or associated with sEVs. Ejaculated spermatozoa expressed all three TGF-beta isoforms, both inside and outside, probably the outer one associated with membrane-bound sEVs. The results confirmed that pig SP contains all three TGF-beta isoforms and demonstrated that a substantial portion of them is associated with sEVs. Discussion : Seminal EVs would be involved in the cellular secretion of the active forms of seminal TGF-beta isoforms and in their safe transport from the male to the female reproductive tract.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Barranco, IsabelUniv Murcia, Spain; Univ Bologna, Italy; Univ Murcia, Spain
(författare)
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Martinez-Hernandez, JesusUniv Murcia, Spain; Univ Murcia, Spain
(författare)
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Parra, AnaUniv Murcia, Spain; Univ Murcia, Spain
(författare)
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Parrilla, InmaculadaUniv Murcia, Spain; Univ Murcia, Spain
(författare)
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Pastor, Luis MiguelUniv Murcia, Spain; Univ Murcia, Spain
(författare)
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Rodriguez-Martinez, HeribertoLinköpings universitet,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten(Swepub:liu)herro55
(författare)
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Lucas, XiomaraUniv Murcia, Spain; Univ Murcia, Spain
(författare)
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Roca, JordiUniv Murcia, Spain; Univ Murcia, Spain
(författare)
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Univ Girona, Spain; Univ Murcia, SpainUniv Murcia, Spain; Univ Bologna, Italy; Univ Murcia, Spain
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Frontiers in Veterinary Science: FRONTIERS MEDIA SA102297-1769
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