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Implementation of W...
Implementation of Whole-Genome and Transcriptome Sequencing Into Clinical Cancer Care
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- Cuppen, Edwin (författare)
- Hartwig Medical Foundation, Amsterdam, the Netherlands;Center for Molecular Medicine and Oncode Institute, University Medical Center, Utrecht, the Netherlands
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- Elemento, Olivier (författare)
- Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, USA
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- Rosenquist, Richard (författare)
- Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden;Clinical Genetics, Karolinska University Hospital, Solna, Sweden
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- Nikic, Svetlana (författare)
- Illumina Productos de España, S.L.U., Plaza Pablo Ruiz Picasso, Madrid, Spain
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- IJzerman, Maarten (författare)
- Erasmus School of Health Policy & Management, Erasmus University, Rotterdam, the Netherlands;Centre for Cancer Research, University of Melbourne, Melbourne, Australia
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- Zaleski, Isabelle Durand (författare)
- Université de Paris, CRESS, INSERM, INRA, URCEco, AP-HP, Hôpital de l'Hôtel Dieu, Paris, France
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- Frederix, Geert (författare)
- Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, the Netherlands
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- Levin, Lars-Åke, Professor, 1960- (författare)
- Linköpings universitet,Avdelningen för samhälle och hälsa,Medicinska fakulteten
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- Mullighan, Charles G. (författare)
- Department of Pathology, St Jude Children's Research Hospital, Memphis, TN, USA
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- Buettner, Reinhard (författare)
- Institute of Pathology, University Hospital Cologne, Germany
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- Pugh, Trevor J. (författare)
- Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada;Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada;Ontario Institute for Cancer Research, Toronto, Ontario, Canada
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- Grimmond, Sean (författare)
- Centre for Cancer Research, University of Melbourne, Melbourne, Australia
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- Caldas, Carlos (författare)
- Cancer Research UK Cambridge Institute and Department of Oncology, University of Cambridge, Cambridge, United Kingdom
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- Andre, Fabrice (författare)
- Institut Gustave Roussy, Villejuif, France
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- Custers, Ilse (författare)
- Stichting Lygature, Utrecht, the Netherlands
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- Campo, Elias (författare)
- Institut d’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, Spain;Centro de Investigación Biomédica en Red, Cáncer (CIBERONC), Madrid, Spain;Hematopathology Unit, Hospital Clínic of Barcelona, Barcelona, Spain;University of Barcelona, Barcelona, Spain
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- van Snellenberg, Hans (författare)
- Hartwig Medical Foundation, Amsterdam, the Netherlands
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- Schuh, Anna (författare)
- University of Oxford, Oxford, United Kingdom
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- Nakagawa, Hidewaki (författare)
- Laboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan
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- von Kalle, Christof (författare)
- Berlin Institute of Health at Charité—Universitätsmedizin Berlin, Clinical Study Center, Berlin, Germany
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- Haferlach, Torsten (författare)
- Munich Leukemia Laboratory, Munich, Germany
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- Fröhling, Stefan (författare)
- Division of Translational Medical Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany;German Cancer Consortium (DKTK), Heidelberg, Germany
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- Jobanputra, Vaidehi (författare)
- New York Genome Center; Department of Pathology, Columbia University Irving Medical Center, New York, NY
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(creator_code:org_t)
- American Society of Clinical Oncology, 2022
- 2022
- Engelska.
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Ingår i: JCO Precision Oncology. - : American Society of Clinical Oncology. - 2473-4284. ; 6
- Relaterad länk:
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- PURPOSE The combination of whole-genome and transcriptome sequencing (WGTS) is expected to transformdiagnosis and treatment for patients with cancer. WGTS is a comprehensive precision diagnostic test that isstarting to replace the standard of care for oncology molecular testing in health care systems around the world;however, the implementation and widescale adoption of this best-in-class testing is lacking.METHODS Here, we address the barriers in integrating WGTS for cancer diagnostics and treatment selection andanswer questions regarding utility in different cancer types, cost-effectiveness and affordability, and otherpractical considerations for WGTS implementation.RESULTS We review the current studies implementing WGTS in health care systems and provide a synopsis of theclinical evidence and insights into practical considerations for WGTS implementation. We reflect on regulatory,costs, reimbursement, and incidental findings aspects of this test.CONCLUSION WGTS is an appropriate comprehensive clinical test for many tumor types and can replacemultiple, cascade testing approaches currently performed. Decreasing sequencing cost, increasing number ofclinically relevant aberrations and discovery of more complex biomarkers of treatment response, should pave theway for health care systems and laboratories in implementing WGTS into clinical practice, to transform diagnosisand treatment for patients with cancer.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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Cuppen, Edwin
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Elemento, Olivie ...
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Rosenquist, Rich ...
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Nikic, Svetlana
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IJzerman, Maarte ...
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Zaleski, Isabell ...
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Frederix, Geert
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Levin, Lars-Åke, ...
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Mullighan, Charl ...
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Buettner, Reinha ...
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Pugh, Trevor J.
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Grimmond, Sean
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Caldas, Carlos
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Andre, Fabrice
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Custers, Ilse
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Campo, Elias
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van Snellenberg, ...
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Schuh, Anna
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Nakagawa, Hidewa ...
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von Kalle, Chris ...
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Haferlach, Torst ...
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Fröhling, Stefan
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Jobanputra, Vaid ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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JCO Precision On ...
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Linköpings universitet