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Two structurally de...
Two structurally defined A & beta; polymorphs promote different pathological changes in susceptible mice
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- Gomez-Gutierrez, Ruben (författare)
- Univ Texas Hlth Sci Ctr Houston, TX 77030 USA; Univ Malaga, Spain
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- Ghosh, Ujjayini (författare)
- Natl Inst Diabet & Digest & Kidney Dis, MD 20892 USA
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- Yau, Wai-Ming (författare)
- Natl Inst Diabet & Digest & Kidney Dis, MD 20892 USA
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- Gamez, Nazaret (författare)
- Univ Texas Hlth Sci Ctr Houston, TX 77030 USA; Univ Malaga, Spain
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- Do, Katherine (författare)
- Univ Texas Hlth Sci Ctr Houston, TX 77030 USA
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- Kramm, Carlos (författare)
- Univ Texas Hlth Sci Ctr Houston, TX 77030 USA
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- Shirani, Hamid, 1967- (författare)
- Linköpings universitet,Kemi,Tekniska fakulteten
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- Vegas-Gomez, Laura (författare)
- Univ Malaga, Spain
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- Schulz, Jonathan (författare)
- Univ Texas Hlth Sci Ctr Houston, TX 77030 USA
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- Moreno-Gonzalez, Ines (författare)
- Univ Texas Hlth Sci Ctr Houston, TX 77030 USA; Univ Malaga, Spain; Ctr Invest Biomed Red Enfermedades Neurodegenerat, Spain; Univ Bernardo OHiggins, Chile
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- Gutierrez, Antonia (författare)
- Univ Malaga, Spain; Ctr Invest Biomed Red Enfermedades Neurodegenerat, Spain
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- Nilsson, Peter, 1970- (författare)
- Linköpings universitet,Kemi,Tekniska fakulteten
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- Tycko, Robert (författare)
- Natl Inst Diabet & Digest & Kidney Dis, MD 20892 USA
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- Soto, Claudio (författare)
- Univ Texas Hlth Sci Ctr Houston, TX 77030 USA
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- Morales, Rodrigo (författare)
- Univ Texas Hlth Sci Ctr Houston, TX 77030 USA; Univ Bernardo OHiggins, Chile
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(creator_code:org_t)
- WILEY, 2023
- 2023
- Engelska.
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Ingår i: EMBO Reports. - : WILEY. - 1469-221X .- 1469-3178. ; 24:8
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Misfolded A & beta; is involved in the progression of Alzheimers disease (AD). However, the role of its polymorphic variants or conformational strains in AD pathogenesis is not fully understood. Here, we study the seeding properties of two structurally defined synthetic misfolded A & beta; strains (termed 2F and 3F) using in vitro and in vivo assays. We show that 2F and 3F strains differ in their biochemical properties, including resistance to proteolysis, binding to strain-specific dyes, and in vitro seeding. Injection of these strains into a transgenic mouse model produces different pathological features, namely different rates of aggregation, formation of different plaque types, tropism to specific brain regions, differential recruitment of A & beta;(40)/A & beta;(42) peptides, and induction of microglial and astroglial responses. Importantly, the aggregates induced by 2F and 3F are structurally different as determined by ssNMR. Our study analyzes the biological properties of purified A & beta; polymorphs that have been characterized at the atomic resolution level and provides relevant information on the pathological significance of misfolded A & beta; strains.
Ämnesord
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Nyckelord
- amyloid-beta; animal models; prion; protein conformation; strains
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
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Gomez-Gutierrez, ...
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Ghosh, Ujjayini
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Yau, Wai-Ming
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Gamez, Nazaret
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Do, Katherine
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Kramm, Carlos
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visa fler...
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Shirani, Hamid, ...
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Vegas-Gomez, Lau ...
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Schulz, Jonathan
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Moreno-Gonzalez, ...
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Gutierrez, Anton ...
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Nilsson, Peter, ...
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Tycko, Robert
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Soto, Claudio
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Morales, Rodrigo
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visa färre...
- Om ämnet
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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