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Post-COVID sequelae...
Post-COVID sequelae effect in chronic fatigue syndrome: SARS-CoV-2 triggers latent adenovirus in the oral mucosa
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- Hannestad, Ulf (författare)
- Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten
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- Apostolou, Eirini (författare)
- Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten
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- Sjogren, Per (författare)
- Karolinska Institutet
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- Bragee, Bjorn (författare)
- Karolinska Institutet
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- Polo, Olli (författare)
- Bragee Clin, Sweden
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- Bertilson, Bo Christer (författare)
- Karolinska Inst, Sweden; Bragee Clin, Sweden
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- Rosén, Anders (författare)
- Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten
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(creator_code:org_t)
- FRONTIERS MEDIA SA, 2023
- 2023
- Engelska.
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Ingår i: Frontiers in Medicine. - : FRONTIERS MEDIA SA. - 2296-858X. ; 10
- Relaterad länk:
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- The post-viral fatigue syndromes long COVID and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) have multiple, potentially overlapping, pathological processes. These include persisting reservoirs of virus, e.g., SARS-CoV-2 in long COVID patients tissues, immune dysregulation with or without reactivation of underlying pathogens, such as Epstein-Barr virus (EBV) and human herpesvirus 6 (HHV6), as we recently described in ME/CFS, and possibly yet unidentified viruses. In the present study we tested saliva samples from two cohorts for IgG against human adenovirus (HAdV): patients with ME/CFS (n = 84) and healthy controls (n = 94), with either mild/asymptomatic SARS-CoV-2 infection or no infection. A significantly elevated anti-HAdV IgG response after SARS-CoV-2 infection was detected exclusively in the patient cohort. Longitudinal/time analysis, before and after COVID-19, in the very same individuals confirmed HAdV IgG elevation after. In plasma there was no HAdV IgG elevation. We conclude that COVID-19 triggered reactivation of dormant HAdV in the oral mucosa of chronic fatigue patients indicating an exhausted dysfunctional antiviral immune response in ME/CFS, allowing reactivation of adenovirus upon stress encounter such as COVID-19. These novel findings should be considered in clinical practice for identification of patients that may benefit from therapy that targets HAdV as well.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Nyckelord
- post-COVID condition; SARS-CoV-2; myalgic encephalomyelitis; chronic fatigue syndrome; ME; CFS; human adenovirus (HAdV); saliva antibodies; oral mucosa immune response
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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