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Sökning: onr:"swepub:oai:DiVA.org:liu-196748" > Post-COVID sequelae...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003815naa a2200409 4500
001oai:DiVA.org:liu-196748
003SwePub
008230822s2023 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:153184956
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1967482 URI
0247 a https://doi.org/10.3389/fmed.2023.12081812 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1531849562 URI
040 a (SwePub)liud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Hannestad, Ulfu Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten4 aut0 (Swepub:liu)ulfha46
2451 0a Post-COVID sequelae effect in chronic fatigue syndrome: SARS-CoV-2 triggers latent adenovirus in the oral mucosa
264 1b FRONTIERS MEDIA SA,c 2023
338 a electronic2 rdacarrier
520 a The post-viral fatigue syndromes long COVID and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) have multiple, potentially overlapping, pathological processes. These include persisting reservoirs of virus, e.g., SARS-CoV-2 in long COVID patients tissues, immune dysregulation with or without reactivation of underlying pathogens, such as Epstein-Barr virus (EBV) and human herpesvirus 6 (HHV6), as we recently described in ME/CFS, and possibly yet unidentified viruses. In the present study we tested saliva samples from two cohorts for IgG against human adenovirus (HAdV): patients with ME/CFS (n = 84) and healthy controls (n = 94), with either mild/asymptomatic SARS-CoV-2 infection or no infection. A significantly elevated anti-HAdV IgG response after SARS-CoV-2 infection was detected exclusively in the patient cohort. Longitudinal/time analysis, before and after COVID-19, in the very same individuals confirmed HAdV IgG elevation after. In plasma there was no HAdV IgG elevation. We conclude that COVID-19 triggered reactivation of dormant HAdV in the oral mucosa of chronic fatigue patients indicating an exhausted dysfunctional antiviral immune response in ME/CFS, allowing reactivation of adenovirus upon stress encounter such as COVID-19. These novel findings should be considered in clinical practice for identification of patients that may benefit from therapy that targets HAdV as well.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Infektionsmedicin0 (SwePub)302092 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Infectious Medicine0 (SwePub)302092 hsv//eng
653 a post-COVID condition; SARS-CoV-2; myalgic encephalomyelitis; chronic fatigue syndrome; ME; CFS; human adenovirus (HAdV); saliva antibodies; oral mucosa immune response
7001 a Apostolou, Eiriniu Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten4 aut0 (Swepub:liu)eirap47
7001 a Sjogren, Peru Karolinska Inst, Sweden; Bragee Clin, Sweden4 aut
7001 a Bragee, Bjornu Karolinska Inst, Sweden; Bragee Clin, Sweden4 aut
7001 a Polo, Olliu Bragee Clin, Sweden4 aut
7001 a Bertilson, Bo Christeru Karolinska Inst, Sweden; Bragee Clin, Sweden4 aut
7001 a Rosén, Andersu Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten4 aut0 (Swepub:liu)andro72
7102 a Linköpings universitetb Avdelningen för cellbiologi4 org
7730 t Frontiers in Medicined : FRONTIERS MEDIA SAg 10q 10x 2296-858X
8564 u https://liu.diva-portal.org/smash/get/diva2:1790287/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-196748
8564 8u https://doi.org/10.3389/fmed.2023.1208181
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:153184956

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