Modeling cancer’s ecological and evolutionary dynamics

Bukkuri, Anuraag (författare): Lund University,Lunds universitet,Molekylär evolution,Forskargrupper vid Lunds universitet,Molecular Evolution,Lund University Research Groups,H. Lee Moffitt Cancer Center & Research Institute

Pienta, Kenneth J. (författare): Johns Hopkins University School of Medicine

Hammarlund, Emma U. (författare): Lund University,Lunds universitet,Berggrundsgeologi,Geologiska institutionen,Naturvetenskapliga fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Molekylär evolution,Forskargrupper vid Lunds universitet,Lithosphere and Biosphere Science,Department of Geology,Faculty of Science,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Molecular Evolution,Lund University Research Groups

Brown, Joel S. (författare): H. Lee Moffitt Cancer Center & Research Institute

(creator_code:org_t)

2023-02-28
2023
Engelska.
Ingår i: Medical Oncology. - : Springer Science and Business Media LLC. - 1357-0560 .- 1559-131X. ; 40:4

Relaterad länk:: http://dx.doi.org/10... (free); visa fler...; https://lup.lub.lu.s...; https://doi.org/10.1...; visa färre...

Abstract Ämnesord

Stäng

In this didactic paper, we present a theoretical modeling framework, called the G-function, that integrates both the ecology and evolution of cancer to understand oncogenesis. The G-function has been used in evolutionary ecology, but has not been widely applied to problems in cancer. Here, we build the G-function framework from fundamental Darwinian principles and discuss how cancer can be seen through the lens of ecology, evolution, and game theory. We begin with a simple model of cancer growth and add on components of cancer cell competition and drug resistance. To aid in exploration of eco-evolutionary modeling with this approach, we also present a user-friendly software tool. By the end of this paper, we hope that readers will be able to construct basic G function models and grasp the usefulness of the framework to understand the games cancer plays in a biologically mechanistic fashion.

Av författaren/redakt...: Bukkuri, Anuraag; Pienta, Kenneth ...; Hockett, Ian; Austin, Robert H ...; Hammarlund, Emma ...; Amend, Sarah R.; visa fler...; Brown, Joel S.; visa färre...

Om ämnet

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.