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Excessive hair cort...
Excessive hair cortisol concentration as an indicator of psychological disorders in children
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- Braenden, Astrid (författare)
- Oslo Univ Hosp, Norway; Oslo Univ Hosp, Norway
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- Lebena, Andrea (författare)
- Linköpings universitet,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten
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- Olsen Faresjö, Åshild (författare)
- Linköpings universitet,Avdelningen för samhälle och hälsa,Medicinska fakulteten
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- Theodorsson, Elvar (författare)
- Linköpings universitet,Avdelningen för klinisk kemi och farmakologi,Medicinska fakulteten,Region Östergötland, Klinisk kemi
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- Coldevin, Marit (författare)
- Lovisenberg Diaconal Hosp, Norway
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- Stubberud, Jan (författare)
- Lovisenberg Diaconal Hosp, Norway; Univ Oslo, Norway
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- Zeiner, Pal (författare)
- Oslo Univ Hosp, Norway; Univ Oslo, Norway
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- Melinder, Annika (författare)
- Oslo Univ Hosp, Norway; Univ Oslo, Norway
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(creator_code:org_t)
- PERGAMON-ELSEVIER SCIENCE LTD, 2023
- 2023
- Engelska.
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Ingår i: Psychoneuroendocrinology. - : PERGAMON-ELSEVIER SCIENCE LTD. - 0306-4530 .- 1873-3360. ; 157
- Relaterad länk:
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Cortisol in hair is a new biomarker assessing long-term hypothalamic-pituitary-adrenal (HPA) axis activity, which is related to emotion regulation. We compare hair cortisol concentrations (HCC), in clinically referred children with disruptive mood dysregulation disorder (DMDD) (n = 19), children with other types of psychological disorders (n = 48), and healthy subjects (n = 36). We also investigate the association between HCC and irritability, age, and sex. Our results show that children with DMDD or other types of psychological disorders have higher HCC than healthy subjects, p < .001, ?(2)(p) = .39. No difference between children with DMDD and those with other types of psychological disorders was found, p = .91, nor an association between HCC and irritability in the clinical sample, p = .32. We found a significant negative correlation between HCC and age in those with DMDD, r = -0.54, p < .05, but not in the normative sample, r = -0.20, p = .25. No differences in HCC between girls and boys were found in the normative sample, p = .49. Children in need of psychological treatment, including those with DMDD, seem to have dysregulated HPA-axis activity over time. Excessive accumulated cortisol concentrations in hair could be an indicator of a psychological disorder in children.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Nyckelord
- Disruptive mood dysregulation disorder; Cortisol; Stress; Irritability; HPA-axis; Child
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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