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Intravenous iron su...
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Lindgren, StefanLund University,Lunds universitet,Gastroenterologi,Forskargrupper vid Lunds universitet,Enheten för kroniska inflammatoriska och degenerativa sjukdomar,Gastroenterology,Lund University Research Groups,Chronic Inflammatory and Degenerative Diseases Research Unit,Department of Medicine, Gastroenterology-Hepatology Division, University Hospital MAS, Malmö
(författare)
Intravenous iron sucrose is superior to oral iron sulphate for correcting anaemia and restoring iron stores in IBD patients : A randomized, controlled, evaluator-blind, multicentre study
- Artikel/kapitelEngelska2009
Förlag, utgivningsår, omfång ...
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2009-07-21
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Informa UK Limited,2009
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:liu-19887
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-19887URI
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https://doi.org/10.1080/00365520902839667DOI
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https://lup.lub.lu.se/record/1367388URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:119178198URI
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https://gup.ub.gu.se/publication/110193URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Objective. Patients with inflammatory bowel disease (IBD) often have low iron stores or anaemia. There is controversy about whether iron should be supplemented orally or intravenously (i.v.). The purpose of this study was to investigate whether treatment with intravenous iron is superior to treatment with oral iron. The primary end-points were response and remaining anaemia at the end of treatment (EOT).Material and methods. Ninety-one patients with IBD and anaemia (B-Hb <115 g/L) were randomized to oral iron sulphate (n=46) or intravenous iron sucrose (n=45) treatment for 20 weeks.Results. Forty-three patients in the intravenous iron group completed the study compared to 35 patients in the oral iron group (p=0.0009). Only 22 patients (48%) tolerated the prescribed oral dose, and 52% reduced the dose or withdrew from treatment because of poor tolerance. At EOT, 47% patients in the oral iron group increased their B-Hb by ≥20 g/L, compared with 66% in the intravenous iron group (p=0.07). In the oral iron group, 41% still had anaemia versus 16% of the patients in the intravenous iron group (p=0.007), and 22% versus 42% reached their reference B-Hb level (p=0.04). Treatment with intravenous iron sucrose improved iron stores faster and more effectively than oral iron (p=0.002). Under treatment with intravenous iron, 74% of the patients had no anaemia and normal S-ferritin levels (>25 µg/L) at EOT compared with 48% of patients receiving oral iron (p=0.013).Conclusions. Treatment with intravenous iron sucrose is effective, safe, well tolerated and superior to oral iron in correcting haemoglobin and iron stores in patients with IBD.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Wikman, OlaDepartment of Medicine, Södersjukhuset, Stockholm
(författare)
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Befrits, RagnarKarolinska Institutet,Department of Gastroenterology and Hepatology, Karolinska Hospital, Stockholm
(författare)
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Blom, HakanDepartment of Medicine, Sunderby Hospital, Lulea and Östersund Hospital, Östersund
(författare)
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Eriksson, Anders,1957Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för akut och kardiovaskulär medicin,Institute of Medicine, Department of Emergeny and Cardiovascular Medicine,Department of Internal Medicine, Gastroenterology Unit, Sahlgrenska University Hospital/Östra Sjukhuset, Göteborg(Swepub:gu)xeandw
(författare)
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Granno, ChristerDepartment of Medicine, Ryhov Hospital, Jönköping
(författare)
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Ung, Kjell-Arne,1951Department of Medicine Kärnsjukhuset, Skövde(Swepub:gu)xungkj
(författare)
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Hjortswang, HenrikLinköpings universitet,Endokrinologi,Hälsouniversitetet(Swepub:liu)henhj44
(författare)
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Lindgren, AndersDepartment of Medicine, Borås Hospital, Borås
(författare)
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Unge, PeterDepartment of Medicine, Bollnäs Hospital, Bollnäs, Sweden(Swepub:liu)petun61
(författare)
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GastroenterologiForskargrupper vid Lunds universitet
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Scandinavian Journal of Gastroenterology: Informa UK Limited44:7, s. 838-8450036-55211502-7708
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Lindgren, Stefan
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Wikman, Ola
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Befrits, Ragnar
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Blom, Hakan
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Eriksson, Anders ...
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Granno, Christer
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Ung, Kjell-Arne, ...
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Hjortswang, Henr ...
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Lindgren, Anders
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Unge, Peter
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