Sökning: onr:"swepub:oai:DiVA.org:liu-200780" >
Functional SARS-CoV...
Functional SARS-CoV-2 cross-reactive CD4+ T cells established in early childhood decline with age
-
- Humbert, Marion (författare)
- Karolinska Institutet
-
- Olofsson, Anna (författare)
- Karolinska Institutet
-
- Wullimann, David (författare)
- Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Huddinge, Sweden
-
visa fler...
-
- Niessl, Julia (författare)
- Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Sweden
-
- Hodcroft, Emma B. (författare)
- University of Bern, Switzerland; Swiss Institute of Bioinformatics, Sweitzerland
-
- Cai, Curtis (författare)
- Karolinska Institutet
-
- Gao, Yu (författare)
- Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Sweden
-
- Sohlberg, Ebba (författare)
- Karolinska Institutet
-
- Dyrdak, Robert (författare)
- Karolinska Institutet
-
- Mikaeloff, Flora (författare)
- Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, Sweden
-
- Neogi, Ujjwal (författare)
- Karolinska Institutet
-
- Albert, Jan (författare)
- Karolinska Institutet
-
- Malmberg, Karl-Johan (författare)
- Karolinska Institutet
-
- Lund-Johansen, Fridtjof (författare)
- Oslo University Hospital, Norway; University of Oslo, Norway
-
- Aleman, Soo (författare)
- Karolinska Institutet
-
- Björkhem-Bergman, Linda (författare)
- Karolinska Institutet
-
- Jenmalm, Maria, Professor, 1971- (författare)
- Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten
-
- Ljunggren, Hans-Gustaf (författare)
- Karolinska Institutet
-
- Buggert, Marcus (författare)
- Karolinska Institutet
-
- Karlsson, Annika C. (författare)
- Karolinska Institutet, Sweden
-
visa färre...
-
(creator_code:org_t)
- 2023-03-14
- 2023
- Engelska.
-
Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 120:12
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
http://kipublication...
-
http://kipublication...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- Pre-existing SARS-CoV-2-reactive T cells have been identified in SARS-CoV-2-unexposed individuals, potentially modulating COVID-19 and vaccination outcomes. Here, we provide evidence that functional cross-reactive memory CD4+ T cell immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is established in early childhood, mirroring early seroconversion with seasonal human coronavirus OC43. Humoral and cellular immune responses against OC43 and SARS-CoV-2 were assessed in SARS-CoV-2-unexposed children (paired samples at age two and six) and adults (age 26 to 83). Pre-existing SARS-CoV-2-reactive CD4+ T cell responses targeting spike, nucleocapsid, and membrane were closely linked to the frequency of OC43-specific memory CD4+ T cells in childhood. The functional quality of the cross-reactive memory CD4+ T cell responses targeting SARS-CoV-2 spike, but not nucleocapsid, paralleled OC43-specific T cell responses. OC43-specific antibodies were prevalent already at age two. However, they did not increase further with age, contrasting with the antibody magnitudes against HKU1 (β-coronavirus), 229E and NL63 (α-coronaviruses), rhinovirus, Epstein–Barr virus (EBV), and influenza virus, which increased after age two. The quality of the memory CD4+ T cell responses peaked at age six and subsequently declined with age, with diminished expression of interferon (IFN)-γ, interleukin (IL)-2, tumor necrosis factor (TNF), and CD38 in late adulthood. Age-dependent qualitative differences in the pre-existing SARS-CoV-2-reactive T cell responses may reflect the ability of the host to control coronavirus infections and respond to vaccination. Copyright © 2023 the Author(s).
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Nyckelord
- ADP ribosyl cyclase/cyclic ADP ribose hydrolase 1; gamma interferon; interleukin 2; tumor necrosis factor; adult; adulthood; aged; Article; CD4+ T lymphocyte; cellular immunity; child; childhood; comorbidity; controlled study; coronavirus disease 2019; cross reaction; female; human; humoral immunity; major clinical study; male; memory T lymphocyte; nonhuman; protein expression; seroconversion; Severe acute respiratory syndrome coronavirus 2; virus nucleocapsid; virus spike
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Humbert, Marion
-
Olofsson, Anna
-
Wullimann, David
-
Niessl, Julia
-
Hodcroft, Emma B ...
-
Cai, Curtis
-
visa fler...
-
Gao, Yu
-
Sohlberg, Ebba
-
Dyrdak, Robert
-
Mikaeloff, Flora
-
Neogi, Ujjwal
-
Albert, Jan
-
Malmberg, Karl-J ...
-
Lund-Johansen, F ...
-
Aleman, Soo
-
Björkhem-Bergman ...
-
Jenmalm, Maria, ...
-
Ljunggren, Hans- ...
-
Buggert, Marcus
-
Karlsson, Annika ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Medicinska och f ...
-
och Immunologi inom ...
- Artiklar i publikationen
-
Proceedings of t ...
- Av lärosätet
-
Linköpings universitet
-
Karolinska Institutet