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Management of adult...
Management of adult patients with podocytopathies: an update from the ERA Immunonephrology Working Group
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- Mirioglu, Safak (författare)
- Bezmialem Vakif Univ, Turkiye; Istanbul Univ, Turkiye
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- Daniel-Fischer, Lisa (författare)
- Med Univ Vienna, Austria
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- Berke, Ilay (författare)
- Marmara Univ, Turkiye
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- Ahmad, Syed Hasan (författare)
- Cambridge Univ Hosp, England
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- Bajema, Ingeborg M. (författare)
- Univ Groningen, Netherlands
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- Bruchfeld, Annette (författare)
- Karolinska Institutet,Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Njurmedicinska kliniken US,Karolinska Univ Hosp, Sweden; Karolinska Inst, Sweden
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- Fernandez-Juarez, Gema M. (författare)
- Hosp Unv Fdn Alcorcon, Spain
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- Floege, Jurgen (författare)
- RWTH Aachen Univ Hosp, Germany
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- Frangou, Eleni (författare)
- Limassol Gen Hosp, Cyprus; Univ Nicosia, Cyprus
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- Goumenos, Dimitrios (författare)
- Patras Univ Hosp, Greece
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- Griffith, Megan (författare)
- Hammersmith Hosp, England
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- Moran, Sarah M. (författare)
- Univ Coll Cork, Ireland
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- van Kooten, Cees (författare)
- Leiden Univ, Netherlands
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- Steiger, Stefanie (författare)
- Hosp Ludwig Maximilians Univ, Germany
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- Stevens, Kate I (författare)
- Queen Elizabeth Univ Hosp, Scotland
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- Turkmen, Kultigin (författare)
- Necmettin Erbakan Univ, Turkiye
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- Willcocks, Lisa C. (författare)
- Cambridge Univ Hosp, England
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- Kronbichler, Andreas (författare)
- Med Univ Innsbruck, Austria
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(creator_code:org_t)
- OXFORD UNIV PRESS, 2024
- 2024
- Engelska.
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Ingår i: Nephrology, Dialysis and Transplantation. - : OXFORD UNIV PRESS. - 0931-0509 .- 1460-2385. ; 39:4, s. 569-580
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- The histopathological lesions, minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS) are entities without immune complex deposits which can cause podocyte injury, thus are frequently grouped under the umbrella of podocytopathies. Whether MCD and FSGS may represent a spectrum of the same disease remains a matter of conjecture. Both frequently require repeated high-dose glucocorticoid therapy with alternative immunosuppressive treatments reserved for relapsing or resistant cases and response rates are variable. There is an unmet need to identify patients who should receive immunosuppressive therapies as opposed to those who would benefit from supportive strategies. Therapeutic trials focusing on MCD are scarce, and the evidence used for the 2021 Kidney Disease: Improving Global Outcomes (KDIGO) guideline for the management of glomerular diseases largely stems from observational and pediatric trials. In FSGS, the differentiation between primary forms and those with underlying genetic variants or secondary forms further complicates trial design. This article provides a perspective of the Immunonephrology Working Group (IWG) of the European Renal Association (ERA) and discusses the KDIGO 2021 Clinical Practice Guideline for the Management of Glomerular Diseases focusing on the management of MCD and primary forms of FSGS in the context of recently published evidence, with a special emphasis on the role of rituximab, cyclophosphamide, supportive treatment options and ongoing clinical trials in the field. 10.1093/ndt/gfae025 Video Watch the video of this contribution at https://academic.oup.com/ndt/pages/author_videos gfae025Media1 6346336829112
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Nyckelord
- FSGS; guideline; KDIGO; MCD; podocytopathy
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Mirioglu, Safak
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Daniel-Fischer, ...
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Berke, Ilay
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Ahmad, Syed Hasa ...
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Bajema, Ingeborg ...
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Bruchfeld, Annet ...
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Fernandez-Juarez ...
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Floege, Jurgen
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Frangou, Eleni
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Goumenos, Dimitr ...
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Griffith, Megan
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Moran, Sarah M.
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van Kooten, Cees
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Steiger, Stefani ...
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Stevens, Kate I
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Turkmen, Kultigi ...
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Willcocks, Lisa ...
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Kronbichler, And ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Urologi och njur ...
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Linköpings universitet
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Karolinska Institutet