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Artificial intellig...
Artificial intelligence in digital pathology: a systematic review and meta-analysis of diagnostic test accuracy
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- Mcgenity, Clare (författare)
- Univ Leeds, England; Leeds Teaching Hosp NHS Trust, England
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- Clarke, Emily L. (författare)
- Univ Leeds, England; Leeds Teaching Hosp NHS Trust, England
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- Jennings, Charlotte (författare)
- Univ Leeds, England; Leeds Teaching Hosp NHS Trust, England
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- Matthews, Gillian (författare)
- Leeds Teaching Hosp NHS Trust, England
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- Cartlidge, Caroline (författare)
- Univ Leeds, England
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- Freduah-Agyemang, Henschel (författare)
- Univ Leeds, England
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- Stocken, Deborah D. (författare)
- Univ Leeds, England
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- Treanor, Darren (författare)
- Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Region Östergötland, Klinisk patologi,Univ Leeds, England; Leeds Teaching Hosp NHS Trust, England
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(creator_code:org_t)
- NATURE PORTFOLIO, 2024
- 2024
- Engelska.
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Ingår i: npj Digital Medicine. - : NATURE PORTFOLIO. - 2398-6352. ; 7:1
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Ensuring diagnostic performance of artificial intelligence (AI) before introduction into clinical practice is essential. Growing numbers of studies using AI for digital pathology have been reported over recent years. The aim of this work is to examine the diagnostic accuracy of AI in digital pathology images for any disease. This systematic review and meta-analysis included diagnostic accuracy studies using any type of AI applied to whole slide images (WSIs) for any disease. The reference standard was diagnosis by histopathological assessment and/or immunohistochemistry. Searches were conducted in PubMed, EMBASE and CENTRAL in June 2022. Risk of bias and concerns of applicability were assessed using the QUADAS-2 tool. Data extraction was conducted by two investigators and meta-analysis was performed using a bivariate random effects model, with additional subgroup analyses also performed. Of 2976 identified studies, 100 were included in the review and 48 in the meta-analysis. Studies were from a range of countries, including over 152,000 whole slide images (WSIs), representing many diseases. These studies reported a mean sensitivity of 96.3% (CI 94.1-97.7) and mean specificity of 93.3% (CI 90.5-95.4). There was heterogeneity in study design and 99% of studies identified for inclusion had at least one area at high or unclear risk of bias or applicability concerns. Details on selection of cases, division of model development and validation data and raw performance data were frequently ambiguous or missing. AI is reported as having high diagnostic accuracy in the reported areas but requires more rigorous evaluation of its performance.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik -- Medicinsk bildbehandling (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering -- Medical Image Processing (hsv//eng)
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