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Probabilistic stimu...
Probabilistic stimulation mapping from intra-operative thalamic deep brain stimulation data in essential tremor
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- Vogel, Dorian (författare)
- Univ Appl Sci & Arts Northwestern Switzerland, Switzerland
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- Nordin, Teresa (författare)
- Linköpings universitet,Avdelningen för medicinsk teknik,Tekniska fakulteten
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- Feiler, Stefanie (författare)
- Univ Appl Sci & Arts Northwestern Switzerland, Switzerland
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- Wårdell, Karin (författare)
- Linköpings universitet,Avdelningen för medicinsk teknik,Tekniska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Univ Appl Sci & Arts Northwestern Switzerland, Switzerland
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- Coste, Jerome (författare)
- Univ Clermont Auvergne, France; Hop Gabriel Montpied, France
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- Lemaire, Jean-Jacques (författare)
- Univ Clermont Auvergne, France; Hop Gabriel Montpied, France
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- Hemm-Ode, Simone (författare)
- Linköpings universitet,Avdelningen för medicinsk teknik,Tekniska fakulteten,Univ Appl Sci & Arts Northwestern Switzerland, Switzerland
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(creator_code:org_t)
- IOP Publishing Ltd, 2024
- 2024
- Engelska.
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Ingår i: Journal of Neural Engineering. - : IOP Publishing Ltd. - 1741-2560 .- 1741-2552. ; 21:3
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Deep brain stimulation (DBS) is a therapy for Parkinson's disease (PD) and essential tremor (ET). The mechanism of action of DBS is still incompletely understood. Retrospective group analysis of intra-operative data recorded from ET patients implanted in the ventral intermediate nucleus of the thalamus (Vim) is rare. Intra-operative stimulation tests generate rich data and their use in group analysis has not yet been explored. Objective. To implement, evaluate, and apply a group analysis workflow to generate probabilistic stimulation maps (PSMs) using intra-operative stimulation data from ET patients implanted in Vim. Approach. A group-specific anatomical template was constructed based on the magnetic resonance imaging scans of 6 ET patients and 13 PD patients. Intra-operative test data (total: n = 1821) from the 6 ET patients was analyzed: patient-specific electric field simulations together with tremor assessments obtained by a wrist-based acceleration sensor were transferred to this template. Occurrence and weighted mean maps were generated. Voxels associated with symptomatic response were identified through a linear mixed model approach to form a PSM. Improvements predicted by the PSM were compared to those clinically assessed. Finally, the PSM clusters were compared to those obtained in a multicenter study using data from chronic stimulation effects in ET. Main results. Regions responsible for improvement identified on the PSM were in the posterior sub-thalamic area (PSA) and at the border between the Vim and ventro-oral nucleus of the thalamus (VO). The comparison with literature revealed a center-to-center distance of less than 5 mm and an overlap score (Dice) of 0.4 between the significant clusters. Our workflow and intra-operative test data from 6 ET-Vim patients identified effective stimulation areas in PSA and around Vim and VO, affirming existing medical literature. Significance. This study supports the potential of probabilistic analysis of intra-operative stimulation test data to reveal DBS's action mechanisms and to assist surgical planning.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- deep brain stimulation (DBS); probabilistic stimulation map; atlas; essential tremor; intra-operative stimulation; Vim; quantitative symptoms assessment
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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