Sökning: onr:"swepub:oai:DiVA.org:liu-205164" >
Identification and ...
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Salihovic, Samira,Associate Senior Lecturer,1985-Örebro universitet,Institutionen för medicinska vetenskaper,Orebro Univ, Sweden
(författare)
Identification and validation of a blood- based diagnostic lipidomic signature of pediatric inflammatory bowel disease
- Artikel/kapitelEngelska2024
Förlag, utgivningsår, omfång ...
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NATURE PORTFOLIO,2024
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:liu-205164
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-205164URI
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https://doi.org/10.1038/s41467-024-48763-7DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-114075URI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Funding Agencies|Swedish Foundation for Strategic Research [RB13-0160]; Swedish Research Council [2020-02021]; Orebro University Hospital research foundation [OLL-890291]; NordForsk [90569]
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Improved biomarkers are needed for pediatric inflammatory bowel disease. Here we identify a diagnostic lipidomic signature for pediatric inflammatory bowel disease by analyzing blood samples from a discovery cohort of incident treatment-na & iuml;ve pediatric patients and validating findings in an independent inception cohort. The lipidomic signature comprising of only lactosyl ceramide (d18:1/16:0) and phosphatidylcholine (18:0p/22:6) improves the diagnostic prediction compared with high-sensitivity C-reactive protein. Adding high-sensitivity C-reactive protein to the signature does not improve its performance. In patients providing a stool sample, the diagnostic performance of the lipidomic signature and fecal calprotectin, a marker of gastrointestinal inflammation, does not substantially differ. Upon investigation in a third pediatric cohort, the findings of increased lactosyl ceramide (d18:1/16:0) and decreased phosphatidylcholine (18:0p/22:6) absolute concentrations are confirmed. Translation of the lipidomic signature into a scalable diagnostic blood test for pediatric inflammatory bowel disease has the potential to support clinical decision making. Diagnostic blood-based biomarkers of pediatric IBD are limited. Here, the authors demonstrate a diagnostic lipidomic signature, comprising only of two molecular lipids. Translation of this signature into a scalable test has the potential to support clinical decision making.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Nystrom, NiklasUppsala Univ, Sweden,Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden
(författare)
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Mathisen, Charlotte Bache-WiigOslo Univ Hosp, Norway; Univ Oslo, Norway,Department of Gastroenterology, Oslo University Hospital, Oslo, Norway and Faculty of Medicine, University of Oslo, Oslo, Norway
(författare)
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Kruse, Robert,1972-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Clinical Research Laboratory, Faculty of Medicine and Health, Örebro University, Örebro, Sweden,Orebro Univ, Sweden(Swepub:oru)rke
(författare)
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Olbjorn, ChristineAkershus Univ Hosp, Norway,Department of Pediatrics and Adolescent Medicine, Akershus University Hospital, Lørenskog, Norway
(författare)
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Andersen, SvendVestfold Hosp Trust, Norway,Department of Pediatrics, Vestfold Hospital Trust, Tønsberg, Norway
(författare)
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Noble, Alexandra J.Univ Oxford, England,Translational Gastroenterology Unit, Nuffield Department of Experimental Medicine, University of Oxford, Oxford, United Kingdom; Biomedical Research Center, University of Oxford, Oxford, United Kingdom
(författare)
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Dorn-Rasmussen, MariaCopenhagen Univ Hosp Amager & Hvidovre, Denmark; Copenhagen Univ Hosp Amager & Hvidovre, Denmark,Department of Paediatric and Adolescence Medicine, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark; Copenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark
(författare)
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Bazov, Igor,1973-Örebro universitet,Institutionen för medicinska vetenskaper,Orebro Univ, Sweden(Swepub:oru)ibv
(författare)
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Perminow, GoriOslo Univ Hosp, Norway,Department of Pediatric Medicine, Oslo University Hospital, Oslo, Norway
(författare)
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Opheim, RandiOslo Univ Hosp, Norway; Univ Oslo, Norway,Department of Gastroenterology, Oslo University Hospital, Oslo, Norway and Faculty of Medicine, University of Oslo, Oslo, Norway
(författare)
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Detlie, Trond EspenAkershus Univ Hosp, Norway; Univ Oslo, Norway,Department of Gastroenterology, Akershus University Hospital, Lørenskog, Norway and Faculty of Medicine, University of Oslo, Oslo, Norway
(författare)
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Huppertz-Hauss, GertTelemark Hosp Trust, Norway,Department of Gastroenterology, Telemark Hospital Trust, Skien, Norway
(författare)
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Hedin, Charlotte R. H.Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden,Karolinska Institutet, Department of Medicine Solna, Stockholm, Sweden; Karolinska University Hospital, Gastroenterology unit, Department of Gastroenterology, Dermatovenereology and Rheumatology, Stockholm, Sweden
(författare)
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Carlson, MarieUppsala Univ, Sweden,Department of Medical Sciences, Uppsala University, Uppsala, Sweden
(författare)
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Ohman, LenaUniv Gothenburg, Sweden,Department of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
(författare)
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Magnusson, Maria K.Univ Gothenburg, Sweden,Department of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
(författare)
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Keita, ÅsaLinköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden(Swepub:liu)asave24
(författare)
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Söderholm, Johan DLinköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Kirurgiska kliniken US,Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden(Swepub:liu)sodda63
(författare)
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D'Amato, MauroBasque Fdn Sci, Spain; CIC bioGUNE BRTA, Spain; LUM Univ, Italy,IKERBASQUE, Basque Foundation for Science, Bilbao, Spain; Gastrointestinal Genetics Lab, CIC bioGUNE - BRTA, Derio, Spain; Department of Medicine & Surgery, LUM University, Casamassima, Italy
(författare)
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Oresic, Matej,1967-Örebro universitet,Institutionen för medicinska vetenskaper,Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland,Orebro Univ, Sweden; Univ Turku, Finland; Abo Akad Univ, Finland(Swepub:oru)moc
(författare)
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Wewer, VibekeCopenhagen Univ Hosp Amager & Hvidovre, Denmark; Copenhagen Univ Hosp Amager & Hvidovre, Denmark,Department of Paediatric and Adolescence Medicine, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark; Copenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark
(författare)
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Satsangi, JackUniv Oxford, England; Univ Oxford, England,Translational Gastroenterology Unit, Nuffield Department of Experimental Medicine, University of Oxford, Oxford, United Kingdom; Biomedical Research Center, University of Oxford, Oxford, United Kingdom
(författare)
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Lindqvist, Carl Mårten,1979-Örebro universitet,Institutionen för medicinska vetenskaper,Orebro Univ, Sweden(Swepub:oru)melt
(författare)
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Burisch, JohanCopenhagen Univ Hosp Amager & Hvidovre, Denmark; Copenhagen Univ Hosp Amager & Hvidovre, Denmark,Copenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark; Gastrounit, medical division, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark
(författare)
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Uhlig, Holm H.Univ Oxford, England; Univ Oxford, England; Univ Oxford, England,Translational Gastroenterology Unit, Nuffield Department of Experimental Medicine, University of Oxford, Oxford, United Kingdom; Biomedical Research Center, University of Oxford, Oxford, United Kingdom; Department of Paediatrics, University of Oxford, Oxford, UK
(författare)
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Repsilber, Dirk,1971-Örebro universitet,Institutionen för medicinska vetenskaper,Orebro Univ, Sweden(Swepub:oru)drr
(författare)
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Hyötyläinen, Tuulia,1971-Örebro universitet,Institutionen för naturvetenskap och teknik,Orebro Univ, Sweden(Swepub:oru)tihn
(författare)
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Hoivik, Marte LieOslo Univ Hosp, Norway; Univ Oslo, Norway,Department of Gastroenterology, Oslo University Hospital, Oslo, Norway and Faculty of Medicine, University of Oslo, Oslo, Norway
(författare)
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Halfvarson, Jonas,1970-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden,Orebro Univ, Sweden(Swepub:oru)jshn
(författare)
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Örebro universitetInstitutionen för medicinska vetenskaper
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Nature Communications: NATURE PORTFOLIO15:12041-1723
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Till lärosätets databas
- Av författaren/redakt...
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Salihovic, Samir ...
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Nystrom, Niklas
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Mathisen, Charlo ...
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Kruse, Robert, 1 ...
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Olbjorn, Christi ...
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Andersen, Svend
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visa fler...
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Noble, Alexandra ...
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Dorn-Rasmussen, ...
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Bazov, Igor, 197 ...
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Perminow, Gori
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Opheim, Randi
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Detlie, Trond Es ...
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Huppertz-Hauss, ...
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Hedin, Charlotte ...
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Carlson, Marie
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Ohman, Lena
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Magnusson, Maria ...
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Keita, Åsa
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Söderholm, Johan ...
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D'Amato, Mauro
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Oresic, Matej, 1 ...
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Wewer, Vibeke
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Satsangi, Jack
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Lindqvist, Carl ...
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Burisch, Johan
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Uhlig, Holm H.
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Repsilber, Dirk, ...
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Hyötyläinen, Tuu ...
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Hoivik, Marte Li ...
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Halfvarson, Jona ...
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