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  • Salihovic, Samira,Associate Senior Lecturer,1985-Örebro universitet,Institutionen för medicinska vetenskaper,Orebro Univ, Sweden (författare)

Identification and validation of a blood- based diagnostic lipidomic signature of pediatric inflammatory bowel disease

  • Artikel/kapitelEngelska2024

Förlag, utgivningsår, omfång ...

  • NATURE PORTFOLIO,2024
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:liu-205164
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-205164URI
  • https://doi.org/10.1038/s41467-024-48763-7DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-114075URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding Agencies|Swedish Foundation for Strategic Research [RB13-0160]; Swedish Research Council [2020-02021]; Orebro University Hospital research foundation [OLL-890291]; NordForsk [90569]
  • Improved biomarkers are needed for pediatric inflammatory bowel disease. Here we identify a diagnostic lipidomic signature for pediatric inflammatory bowel disease by analyzing blood samples from a discovery cohort of incident treatment-na & iuml;ve pediatric patients and validating findings in an independent inception cohort. The lipidomic signature comprising of only lactosyl ceramide (d18:1/16:0) and phosphatidylcholine (18:0p/22:6) improves the diagnostic prediction compared with high-sensitivity C-reactive protein. Adding high-sensitivity C-reactive protein to the signature does not improve its performance. In patients providing a stool sample, the diagnostic performance of the lipidomic signature and fecal calprotectin, a marker of gastrointestinal inflammation, does not substantially differ. Upon investigation in a third pediatric cohort, the findings of increased lactosyl ceramide (d18:1/16:0) and decreased phosphatidylcholine (18:0p/22:6) absolute concentrations are confirmed. Translation of the lipidomic signature into a scalable diagnostic blood test for pediatric inflammatory bowel disease has the potential to support clinical decision making. Diagnostic blood-based biomarkers of pediatric IBD are limited. Here, the authors demonstrate a diagnostic lipidomic signature, comprising only of two molecular lipids. Translation of this signature into a scalable test has the potential to support clinical decision making.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Nystrom, NiklasUppsala Univ, Sweden,Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden (författare)
  • Mathisen, Charlotte Bache-WiigOslo Univ Hosp, Norway; Univ Oslo, Norway,Department of Gastroenterology, Oslo University Hospital, Oslo, Norway and Faculty of Medicine, University of Oslo, Oslo, Norway (författare)
  • Kruse, Robert,1972-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Clinical Research Laboratory, Faculty of Medicine and Health, Örebro University, Örebro, Sweden,Orebro Univ, Sweden(Swepub:oru)rke (författare)
  • Olbjorn, ChristineAkershus Univ Hosp, Norway,Department of Pediatrics and Adolescent Medicine, Akershus University Hospital, Lørenskog, Norway (författare)
  • Andersen, SvendVestfold Hosp Trust, Norway,Department of Pediatrics, Vestfold Hospital Trust, Tønsberg, Norway (författare)
  • Noble, Alexandra J.Univ Oxford, England,Translational Gastroenterology Unit, Nuffield Department of Experimental Medicine, University of Oxford, Oxford, United Kingdom; Biomedical Research Center, University of Oxford, Oxford, United Kingdom (författare)
  • Dorn-Rasmussen, MariaCopenhagen Univ Hosp Amager & Hvidovre, Denmark; Copenhagen Univ Hosp Amager & Hvidovre, Denmark,Department of Paediatric and Adolescence Medicine, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark; Copenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark (författare)
  • Bazov, Igor,1973-Örebro universitet,Institutionen för medicinska vetenskaper,Orebro Univ, Sweden(Swepub:oru)ibv (författare)
  • Perminow, GoriOslo Univ Hosp, Norway,Department of Pediatric Medicine, Oslo University Hospital, Oslo, Norway (författare)
  • Opheim, RandiOslo Univ Hosp, Norway; Univ Oslo, Norway,Department of Gastroenterology, Oslo University Hospital, Oslo, Norway and Faculty of Medicine, University of Oslo, Oslo, Norway (författare)
  • Detlie, Trond EspenAkershus Univ Hosp, Norway; Univ Oslo, Norway,Department of Gastroenterology, Akershus University Hospital, Lørenskog, Norway and Faculty of Medicine, University of Oslo, Oslo, Norway (författare)
  • Huppertz-Hauss, GertTelemark Hosp Trust, Norway,Department of Gastroenterology, Telemark Hospital Trust, Skien, Norway (författare)
  • Hedin, Charlotte R. H.Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden,Karolinska Institutet, Department of Medicine Solna, Stockholm, Sweden; Karolinska University Hospital, Gastroenterology unit, Department of Gastroenterology, Dermatovenereology and Rheumatology, Stockholm, Sweden (författare)
  • Carlson, MarieUppsala Univ, Sweden,Department of Medical Sciences, Uppsala University, Uppsala, Sweden (författare)
  • Ohman, LenaUniv Gothenburg, Sweden,Department of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden (författare)
  • Magnusson, Maria K.Univ Gothenburg, Sweden,Department of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden (författare)
  • Keita, ÅsaLinköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden(Swepub:liu)asave24 (författare)
  • Söderholm, Johan DLinköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Kirurgiska kliniken US,Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden(Swepub:liu)sodda63 (författare)
  • D'Amato, MauroBasque Fdn Sci, Spain; CIC bioGUNE BRTA, Spain; LUM Univ, Italy,IKERBASQUE, Basque Foundation for Science, Bilbao, Spain; Gastrointestinal Genetics Lab, CIC bioGUNE - BRTA, Derio, Spain; Department of Medicine & Surgery, LUM University, Casamassima, Italy (författare)
  • Oresic, Matej,1967-Örebro universitet,Institutionen för medicinska vetenskaper,Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland,Orebro Univ, Sweden; Univ Turku, Finland; Abo Akad Univ, Finland(Swepub:oru)moc (författare)
  • Wewer, VibekeCopenhagen Univ Hosp Amager & Hvidovre, Denmark; Copenhagen Univ Hosp Amager & Hvidovre, Denmark,Department of Paediatric and Adolescence Medicine, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark; Copenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark (författare)
  • Satsangi, JackUniv Oxford, England; Univ Oxford, England,Translational Gastroenterology Unit, Nuffield Department of Experimental Medicine, University of Oxford, Oxford, United Kingdom; Biomedical Research Center, University of Oxford, Oxford, United Kingdom (författare)
  • Lindqvist, Carl Mårten,1979-Örebro universitet,Institutionen för medicinska vetenskaper,Orebro Univ, Sweden(Swepub:oru)melt (författare)
  • Burisch, JohanCopenhagen Univ Hosp Amager & Hvidovre, Denmark; Copenhagen Univ Hosp Amager & Hvidovre, Denmark,Copenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark; Gastrounit, medical division, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark (författare)
  • Uhlig, Holm H.Univ Oxford, England; Univ Oxford, England; Univ Oxford, England,Translational Gastroenterology Unit, Nuffield Department of Experimental Medicine, University of Oxford, Oxford, United Kingdom; Biomedical Research Center, University of Oxford, Oxford, United Kingdom; Department of Paediatrics, University of Oxford, Oxford, UK (författare)
  • Repsilber, Dirk,1971-Örebro universitet,Institutionen för medicinska vetenskaper,Orebro Univ, Sweden(Swepub:oru)drr (författare)
  • Hyötyläinen, Tuulia,1971-Örebro universitet,Institutionen för naturvetenskap och teknik,Orebro Univ, Sweden(Swepub:oru)tihn (författare)
  • Hoivik, Marte LieOslo Univ Hosp, Norway; Univ Oslo, Norway,Department of Gastroenterology, Oslo University Hospital, Oslo, Norway and Faculty of Medicine, University of Oslo, Oslo, Norway (författare)
  • Halfvarson, Jonas,1970-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden,Orebro Univ, Sweden(Swepub:oru)jshn (författare)
  • Örebro universitetInstitutionen för medicinska vetenskaper (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Nature Communications: NATURE PORTFOLIO15:12041-1723

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