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Associations between obesity, a composite risk score for probable long COVID, and sleep problems in SARS-CoV-2 vaccinated individuals
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- Xue, Pei (författare)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Uppsala Univ, Sweden
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- Merikanto, Ilona (författare)
- Univ Helsinki, Finland
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- Delale, Eva A. (författare)
- Inst Anthropol Res, Croatia
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- Bjelajac, Adrijana (författare)
- Inst Med Res & Occupat Hlth, Croatia
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- Yordanova, Juliana (författare)
- Bulgarian Acad Sci, Bulgaria
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- Chan, Rachel N. Y. (författare)
- Chinese Univ Hong Kong, Peoples R China
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- Korman, Maria (författare)
- Ariel Univ, Israel
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- Mota-Rolim, Sergio A. (författare)
- Univ Fed Rio Grande do Norte, Brazil
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- Landtblom, Anne-Marie (författare)
- Linköpings universitet,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Avdelningen för cell- och neurobiologi,Medicinska fakulteten,Region Östergötland, Neurologiska kliniken i Linköping,Department of Medical Sciences, Uppsala University, Uppsala, Sweden
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- Matsui, Kentaro (författare)
- Natl Ctr Hosp, Japan
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- Reis, Catia (författare)
- Univ Lisbon, Portugal; Univ Catolica Portuguesa, Portugal
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- Penzel, Thomas (författare)
- Charite, Germany
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- Inoue, Yuichi (författare)
- Tokyo Med Univ, Japan; Japan Somnol Ctr, Japan
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- Nadorff, Michael R. (författare)
- Mississippi State Univ, MI USA; Baylor Coll Med, TX USA
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- Holzinger, Brigitte (författare)
- Med Univ Vienna, Austria
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- Morin, Charles M. (författare)
- Univ Laval, Canada
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- Espie, Colin A. (författare)
- Univ Oxford, England
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- Plazzi, Giuseppe (författare)
- IRCCS Ist Sci Neurolog Bologna, Italy; Univ Modena & Reggio Emilia, Italy
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- De Gennaro, Luigi (författare)
- Sapienza Univ Rome, Italy; IRCCS Fdn St Lucia, Italy
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- Chung, Frances (författare)
- Univ Toronto, Canada
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- Bjorvatn, Bjorn (författare)
- Univ Bergen, Norway; Haukeland Hosp, Norway
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- Wing, Yun Kwok (författare)
- Chinese Univ Hong Kong, Peoples R China
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- Dauvilliers, Yves (författare)
- CHU, France; Univ Montpellier, France
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- Partinen, Markku (författare)
- Univ Helsinki, Finland; Terveystalo Healthcare Serv, Finland
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- Benedict, Christian, Docent, 1976- (författare)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Uppsala Univ, Sweden
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(creator_code:org_t)
- 2024
- 2024
- Engelska.
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Ingår i: International Journal of Obesity. - : SPRINGERNATURE. - 0307-0565 .- 1476-5497.
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Background: Preliminary data suggests that obesity might hasten the decline in mRNA vaccine-induced immunity against SARS-CoV-2. However, whether this renders individuals with obesity more susceptible to long COVID symptoms post-vaccination remains uncertain. Given sleep's critical role in immunity, exploring the associations between obesity, probable long COVID symptoms, and sleep disturbances is essential. Methods: We analyzed data from a survey of 5919 adults aged 18 to 89, all of whom received two SARS-CoV-2 mRNA vaccinations. Participants were categorized into normal weight, overweight, and obesity groups based on ethnicity-specific BMI cutoffs. The probability of long COVID was evaluated using the Post-Acute Sequelae of SARS-CoV-2 (PASC) score, as our survey did not permit confirmation of acute SARS-CoV-2 infection through methods such as antibody testing. Additionally, sleep patterns were assessed through questionnaires. Results: Participants with obesity exhibited a significantly higher adjusted odds ratio (OR) of having a PASC score of 12 or higher, indicative of probable long COVID in our study, compared to those with normal weight (OR: 1.55, 95% CI: 1.05, 2.28). No significant difference was observed for overweight individuals (OR: 0.92 [95% CI: 0.63, 1.33]). Both obesity and probable long COVID were associated with increased odds of experiencing a heightened sleep burden, such as the presence of obstructive sleep apnea or insomnia (P < 0.001). However, no significant interaction between BMI and probable long COVID status was found. Conclusions: Even post-vaccination, individuals with obesity may encounter a heightened risk of experiencing prolonged COVID-19 symptoms. However, confirming our observations necessitates comprehensive studies incorporating rigorous COVID infection testing, such as antibody assays - unavailable in our anonymous survey. Additionally, it is noteworthy that the correlation between probable long COVID and sleep disturbances appears to be independent of BMI.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Xue, Pei
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Merikanto, Ilona
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Delale, Eva A.
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Bjelajac, Adrija ...
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Yordanova, Julia ...
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Chan, Rachel N. ...
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visa fler...
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Korman, Maria
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Mota-Rolim, Serg ...
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Landtblom, Anne- ...
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Matsui, Kentaro
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Reis, Catia
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Penzel, Thomas
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Inoue, Yuichi
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Nadorff, Michael ...
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Holzinger, Brigi ...
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Morin, Charles M ...
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Espie, Colin A.
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Plazzi, Giuseppe
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De Gennaro, Luig ...
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Chung, Frances
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Bjorvatn, Bjorn
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Wing, Yun Kwok
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Dauvilliers, Yve ...
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Partinen, Markku
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Benedict, Christ ...
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- MEDICIN OCH HÄLSOVETENSKAP
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och Endokrinologi oc ...
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Linköpings universitet
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