Sökning: onr:"swepub:oai:DiVA.org:liu-207173" >
Symptomatic osteone...
Symptomatic osteonecrosis in children treated for Hodgkin lymphoma: A population-based study in Sweden, Finland, and Denmark
-
- Giertz, Mia (författare)
- Uppsala Univ, Sweden; Uppsala Univ Hosp, Sweden
-
- Aarnivala, Henri (författare)
- Oulu Univ Hosp, Finland; Univ Oulu, Finland
-
- Michelsen, Sascha Wilk (författare)
- Univ Hosp Copenhagen, Denmark
-
visa fler...
-
- Bjorklund, Caroline (författare)
- Umea Univ Hosp, Sweden
-
- Englund, Annika (författare)
- Uppsala Univ, Sweden; Uppsala Univ Hosp, Sweden
-
- Gronroos, Marika (författare)
- Turku Univ Hosp, Finland
-
- Hjalgrim, Lisa Lyngsie (författare)
- Univ Hosp Copenhagen, Denmark
-
- Huttunen, Pasi (författare)
- Helsinki Univ Hosp, Finland
-
- Niinimaki, Tuukka (författare)
- Univ Oulu, Finland; Oulu Univ Hosp, Finland
-
- Penno, Eva (författare)
- Uppsala Univ, Sweden
-
- Poyhonen, Tuuli (författare)
- Kuopio Univ Hosp, Finland
-
- Raittinen, Paeivi (författare)
- Tampere Univ & Univ Hosp, Finland
-
- Ranta, Susanna (författare)
- Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden
-
- Svahn, Johan E. (författare)
- Lund Univ, Sweden
-
- Törnudd, Lisa (författare)
- Linköpings universitet,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten,Region Östergötland, H.K.H. Kronprinsessan Victorias barn- och ungdomssjukhus
-
- Niinimaki, Riitta (författare)
- Oulu Univ Hosp, Finland; Univ Oulu, Finland
-
- Harila, Arja (författare)
- Uppsala Univ, Sweden; Uppsala Univ Hosp, Sweden
-
visa färre...
-
(creator_code:org_t)
- 2024
- 2024
- Engelska.
-
Ingår i: Pediatric Blood & Cancer. - : WILEY. - 1545-5009 .- 1545-5017.
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- Background: Osteonecrosis (ON) is a potentially disabling skeletal complication of cancer treatment. Although symptomatic osteonecrosis (sON) is well-known in acute lymphoblastic leukemia (ALL), with an incidence around 6%, studies on sON in pediatric Hodgkin lymphoma (HL) are scarce. The aim of this study was to examine the incidence, risk factors, and outcome of sON in children treated for HL. Procedure: A total of 490 children under 18, diagnosed with HL between 2005 and 2019 in Sweden, Finland, and Denmark were eligible for the study. Data on patient characteristics, HL treatment, and development of sON were collected from patients' medical records. Magnetic resonance imaging scans were used to establish ON diagnosis and grade ON according to the Niinim & auml;ki grading system. Results: Cumulative 2-year incidence of sON among the 489 included patients was 5.5% (n = 30). The risk for developing sON was higher for those with older age (odds ratio [OR] 1.25, 95% confidence interval [CI]: 1.05-1.49, p < .010), female sex (OR 4.45, CI 1.87-10.58, p < .001), high total cumulative glucocorticoid (GC) doses (OR 1.76, 95% CI: 1.21-2.56, p = 0.003), and advanced HL (OR 2.19, 95% CI: 1.03-4.65, p = .042). Four (13.3%) patients underwent major surgical procedures and 13 (43.3%) had persistent symptoms due to ON at follow-up. Conclusions: This study shows that sON is as common in pediatric HL as in pediatric ALL, with risk factors such as older age, female sex, high cumulative GC doses, and advanced HL. Future HL protocol development should aim to reduce the burden of ON by modifying GC treatment.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Nyckelord
- children; Hodgkin lymphoma; osteonecrosis
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Giertz, Mia
-
Aarnivala, Henri
-
Michelsen, Sasch ...
-
Bjorklund, Carol ...
-
Englund, Annika
-
Gronroos, Marika
-
visa fler...
-
Hjalgrim, Lisa L ...
-
Huttunen, Pasi
-
Niinimaki, Tuukk ...
-
Penno, Eva
-
Poyhonen, Tuuli
-
Raittinen, Paeiv ...
-
Ranta, Susanna
-
Svahn, Johan E.
-
Törnudd, Lisa
-
Niinimaki, Riitt ...
-
Harila, Arja
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Pediatrik
- Artiklar i publikationen
-
Pediatric Blood ...
- Av lärosätet
-
Linköpings universitet
-
Karolinska Institutet