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Sökning: onr:"swepub:oai:DiVA.org:liu-21107" > Angiotensin type 1 ...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003427naa a2200385 4500
001oai:DiVA.org:liu-21107
003SwePub
008090929s2006 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-211072 URI
0247 a https://doi.org/10.1097/01.hjh.0000242405.68461.842 DOI
040 a (SwePub)liu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Janke, Ju Franz Volhard Clinic4 aut
2451 0a Angiotensin type 1 receptor antagonists induce human in-vitro adipogenesis through peroxisome prolifertor-activated receptor-gamma activation
264 1b Ovid Technologies (Wolters Kluwer Health),c 2006
338 a print2 rdacarrier
520 a OBJECTIVE: In clonal animal cells, certain angiotensin receptor blockers (ARB) activate the peroxisome proliferator-activated receptor-gamma (PPARgamma). The aim of this work was to validate that observation in human cells and humans. METHODS: We investigated the induction of in-vitro adipogenesis and the activation of PPARgamma-target genes, adiponectin and lipoprotein lipase, by ARB in human preadipocytes. We also studied PPARgamma response-element-driven luciferase reporter gene activation in human adipocytes. Finally, we treated 14 obese men for 10 days with placebo crossed over with 150 mg/day irbesartan. Subcutaneous fat was analyzed for mRNA expression of adiponectin and lipoprotein lipase. RESULTS: Telmisartan and irbesartan, and to a lesser degree losartan, induced adipogenesis and activated PPARgamma-target genes. This stimulation of PPARgamma-target genes was prevented by the PPARgamma antagonist GW9662. Eprosartan had no effect. Paradoxically, all ARB activated the luciferase reporter gene. PPARgamma activity increased approximately two-fold with pioglitazone and 1.5-fold with the ARB in all assays. In the cross-over clinical study, irbesartan lowered blood pressure but had no effect on adiponectin or lipoprotein lipase mRNA expression. CONCLUSIONS: Our data are the first to show that ARB induce adipogenesis and PPARgamma-target gene expression in human adipocytes. Pharmacokinetic differences may contribute to the heterogeneous effects on metabolism and preadipocyte differentiation. In humans, larger doses of ARB, longer treatments, or both may be required to activate PPARgamma in adipose cells.
653 a MEDICINE
653 a MEDICIN
7001 a Schupp, Mu n/a4 aut
7001 a Engeli, Su n/a4 aut
7001 a Gorzelniak, Ku n/a4 aut
7001 a Boschmann, Mu n/a4 aut
7001 a Sauma, Lilianu Östergötlands Läns Landsting,Linköpings universitet,Internmedicin,Hälsouniversitetet,Endokrin- och magtarmmedicinska kliniken US4 aut0 (Swepub:liu)lilsa36
7001 a Nystrom, Fredrik Hu Östergötlands Läns Landsting,Linköpings universitet,Internmedicin,Hälsouniversitetet,Endokrin- och magtarmmedicinska kliniken US4 aut0 (Swepub:liu)freny92
7001 a Jordan, Ju n/a4 aut
7001 a Luft, FCu n/a4 aut
7001 a Sharma, AMu n/a4 aut
7102 a Franz Volhard Clinicb n/a4 org
7730 t Journal of Hypertensiond : Ovid Technologies (Wolters Kluwer Health)g 24:9, s. 1809-1816q 24:9<1809-1816x 0263-6352x 1473-5598
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-21107
8564 8u https://doi.org/10.1097/01.hjh.0000242405.68461.84

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