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Catechol-O-Methyltr...
Catechol-O-Methyltransferase (COMT) gene polymorphism and breast cancer risk in young women
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- Bergman-Jungeström, Malin, 1967- (författare)
- Linköpings universitet,Onkologi,Hälsouniversitetet
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- Wingren, Sten, 1950- (författare)
- Linköpings universitet,Onkologi,Hälsouniversitetet
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(creator_code:org_t)
- 2001-09-11
- 2001
- Engelska.
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Ingår i: British Journal of Cancer. - : Springer Science and Business Media LLC. - 0007-0920 .- 1532-1827. ; 85:6, s. 859-862
- Relaterad länk:
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https://www.nature.c...
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visa fler...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Oestrogen exposure has long been considered to be a main risk factor of breast cancer. More recently, interest has also focused on the possible carcinogenic influence from oestrogen metabolites, such as catechol oestrogens. O-methylation, catalysed by Catechol-O-Methyltransferase (COMT), is one pathway by which the potentially carcinogenic catechol oestrogens can be inactivated. The gene coding for COMT protein contains a single-nucleotide polymorphism (SNP), resulting in an amino acid shift Val Met, which has been shown to determine high- and low-activity configuration of the enzyme. We hypothesized that the low-activity allele, COMTMet, may be implicated in early onset breast cancer. In the present case–control study, including 126 young breast cancer patients ( 36 years) and 117 healthy female blood donors, we analysed the association between COMTMet genotype and risk of breast cancer. No significant difference in the frequency of low-/high-activity alleles was found between cases and controls, indicating that the polymorphism, as a single factor, may not contribute to breast carcinogenesis in young women.
Nyckelord
- Catechol-O-Methyltransferase
- COMT
- genetic polymorphism
- breast cancer
- early onset
- catechol oestrogens
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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