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T and B lymphocyte ...
T and B lymphocyte subsets in patients with unexplained recurrent spontaneous abortion : IVIG versus placebo treatment
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- Jablonowska, Barbara, 1948- (författare)
- Linköpings universitet,Obstetrik och gynekologi,Hälsouniversitetet
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- Palfi, Miodrag, 1954- (författare)
- Linköpings universitet,Transfusionsmedicin,Hälsouniversitetet
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- Matthiesen, Leif, 1954- (författare)
- Linköpings universitet,Obstetrik och gynekologi,Hälsouniversitetet
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- Selbing, Anders, 1946- (författare)
- Linköpings universitet,Obstetrik och gynekologi,Hälsouniversitetet
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- Kjellberg, Svante, 1946- (författare)
- Linköpings universitet,Obstetrik och gynekologi,Hälsouniversitetet
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- Ernerudh, Jan, 1952- (författare)
- Linköpings universitet,Klinisk immunologi,Hälsouniversitetet
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(creator_code:org_t)
- 2003-01-15
- 2002
- Engelska.
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Ingår i: American Journal of Reproductive Immunology. - : Wiley. - 1046-7408 .- 1600-0897. ; 48:5, s. 312-318
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Jablonowska B, Palfi M, Matthiesen L, Selbing A, Kjellberg S, Ernerudh J. T and B Lymphocyte subsets in patients with unexplained recurrent spontaneous abortion: IVIG versus placebo treatment. AJRI 2002; 48:312–318 © Blackwell Munksgaard, 2002PROBLEM: To investigate circulating lymphocyte subsets in women with recurrent spontaneous abortion (RSA) in relation to pregnancy outcome and to treatment with intravenous immunoglobulin (IVIG).METHOD OF STUDY: Forty-one women with a history of unexplained RSA were examined during first trimester of pregnancy before IVIG or placebo treatment and after pregnancy. The results were compared with five healthy, non-pregnant women and five women in the first trimester of normal pregnancy. Circulating lymphocyte subsets with focus on T-cell subpopulations were determined by flow cytometry.RESULTS: The proportions of human leukocyte antigen (HLA)-DR positive T cells (CD3+ HLA-DR+), T-killer/effector cells (CD8+ S6F1+) and B cells (CD19+) were increased, whereas the proportion of T-suppressor/inducer cells (CD4+ CD45RA+) was decreased during first trimester pregnancy of RSA women compared with pregnant normal controls. T and B lymphocyte subsets did not correlate with pregnancy outcome on either IVIG or placebo group.CONCLUSIONS: In RSA patients, the immune system seems to be activated in contrast to the suppression noted in normal pregnancy.
Nyckelord
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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