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Selective effects o...
Selective effects on NGFI-A, MR, GR and NGFI-B hippocampal mRNA expression after chronic treatment with different subclasses of antidepressants in the rat
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- Bjartmar, Lisa, 1966- (författare)
- Linköpings universitet,Hälsouniversitetet,Geriatrik
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- Johansson, Inga-Maj (författare)
- Department of Public Health and Clinical Medicine, Medicine, Umeå University Hospital, Umeå, Sweden
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- Marcusson, Jan, 1958- (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Geriatrik,Geriatriska kliniken
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- Ross, S-B (författare)
- Astra Arcus AB, Södertälje, Sweden
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- Seckl, JR (författare)
- Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Edinburgh, UK
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- Olsson, T (författare)
- Department of Public Health and Clinical Medicine, Medicine, Umeå University Hospital, Umeå, Sweden
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(creator_code:org_t)
- Springer Science and Business Media LLC, 2000
- 2000
- Engelska.
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Ingår i: Psychopharmacology. - : Springer Science and Business Media LLC. - 0033-3158 .- 1432-2072. ; 151:1, s. 7-12
- Relaterad länk:
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http://urn.kb.se/res...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- There is a latency period of several weeks before the onset of clinical effect of antidepressant drugs. The detailed mechanisms underlying drug-induced adaptive neuronal changes are not known. To elucidate the involvement of changes in gene expression of candidate transcription factors, we treated rats for 21 days with buspirone, fluoxetine, 8-OH-DPAT and moclobemide. In situ hybridization was used to study mRNAs encoding NGFI-A, NGFI-B and the glucocorticoid receptors, MR and GR. NGFI-A mRNA expression increased profoundly in the hippocampal formation and the cerebral cortex after all drug treatments, especially after moclobemide treatment (77-122% increase), with the exception of buspirone. MR mRNA expression was induced in hippocampal CA1/CA2 subregions (27-37%) by all antidepressants, while moclobemide and 8-OH-DPAT significantly increased GR gene expression mainly in the CA1 region (31-44%). NGFI-B mRNA was significantly decreased in the hippocampal CA3 subfield (23%) and restrosplenial granular cortex (38%) by moclobemide treatment. There are selective effects of antidepressant drugs on specific transcription factors. These may be important for adaptive neuronal and neuroendocrine changes after antidepressant treatment including HPA axis negative feedback regulation.
Nyckelord
- MEDICINE
- MEDICIN
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- art (ämneskategori)
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