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Sökning: onr:"swepub:oai:DiVA.org:liu-28162" > Gene expression pro...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004067naa a2200529 4500
001oai:DiVA.org:liu-28162
003SwePub
008091008s2004 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:1950136
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-281622 URI
0247 a https://doi.org/10.1073/pnas.03041461012 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:19501362 URI
040 a (SwePub)liud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Lapointe, Jacques4 aut
2451 0a Gene expression profiling identifies clinically relevant subtypes of prostate cancer
264 c 2004-01-07
264 1b Proceedings of the National Academy of Sciences,c 2004
338 a print2 rdacarrier
520 a Prostate cancer, a leading cause of cancer death, displays a broad range of clinical behavior from relatively indolent to aggressive metastatic disease. To explore potential molecular variation underlying this clinical heterogeneity, we profiled gene expression in 62 primary prostate tumors, as well as 41 normal prostate specimens and nine lymph node metastases, using cDNA microarrays containing ≈26,000 genes. Unsupervised hierarchical clustering readily distinguished tumors from normal samples, and further identified three subclasses of prostate tumors based on distinct patterns of gene expression. High-grade and advanced stage tumors, as well as tumors associated with recurrence, were disproportionately represented among two of the three subtypes, one of which also included most lymph node metastases. To further characterize the clinical relevance of tumor subtypes, we evaluated as surrogate markers two genes differentially expressed among tumor subgroups by using immunohistochemistry on tissue microarrays representing an independent set of 225 prostate tumors. Positive staining for MUC1, a gene highly expressed in the subgroups with "aggressive" clinicopathological features, was associated with an elevated risk of recurrence (P = 0.003), whereas strong staining for AZGP1, a gene highly expressed in the other subgroup, was associated with a decreased risk of recurrence (P = 0.0008). In multivariate analysis, MUC1 and AZGP1 staining were strong predictors of tumor recurrence independent of tumor grade, stage, and preoperative prostate-specific antigen levels. Our results suggest that prostate tumors can be usefully classified according to their gene expression patterns, and these tumor subtypes may provide a basis for improved prognostication and treatment stratification.
653 a MEDICINE
653 a MEDICIN
7001 a Li, Chundeu Karolinska Institutet4 aut
7001 a Higgins, John P4 aut
7001 a van de Rijn, Matt4 aut
7001 a Bair, Eric4 aut
7001 a Montgomery, Kelli4 aut
7001 a Ferrari, Michelle4 aut
7001 a Egevad, Larsu Karolinska Institutet4 aut
7001 a Rayford, Walter4 aut
7001 a Bergerheim, Ulf,d 1953-u Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Avdelningen för kirurgi,Urologiska kliniken i Östergötland4 aut0 (Swepub:liu)ulfbe91
7001 a Ekman, Peter4 aut
7001 a DeMarzo, Angelo M4 aut
7001 a Tibshirani, Robert4 aut
7001 a Botstein, David4 aut
7001 a Brown, Patrick O4 aut
7001 a Brooks, James D4 aut
7001 a Pollack, Jonathan R4 aut
7102 a Karolinska Institutetb Hälsouniversitetet4 org
7730 t Proceedings of the National Academy of Sciences of the United States of Americad : Proceedings of the National Academy of Sciencesg 101:3, s. 811-816q 101:3<811-816x 0027-8424x 1091-6490
8564 u https://europepmc.org/articles/pmc321763?pdf=render
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-28162
8564 8u https://doi.org/10.1073/pnas.0304146101
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:1950136

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