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Relationship betwee...
Relationship between the incidence of type 1 diabetes and maternal enterovirus antibodies : Time trends and geographical variation
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- Viskari, H (författare)
- Dept of Virology Tampere, Finland
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- Ludvigsson, Johnny, 1943- (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Pediatrik,Barn- och ungdomskliniken i Linköping
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- Uibo, R (författare)
- Dept of Immunology Tartu, Estonia
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- Salur, L (författare)
- Dept of Immunology, Tartu, Estonia
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- Marciulionyte, D (författare)
- Inst of Endocrinology Kaunas, Lithuania
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- Hermann, R (författare)
- Dept of Pediatrics, Pecs, Hungary
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- Soltesz, G (författare)
- Dept of Pediatrics, Pecs, Hungary
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- Füchtenbusch, M (författare)
- Diabetes Research Institute Munich, Germany
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- Ziegler, A G (författare)
- Diabetes Research Institute Munich, Germany
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- Kondrashova, A (författare)
- Dept of Pediatrics Petrozavodsk, Russia
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- Romanov, A (författare)
- Dept of Pediatrics Petrozavodsk, Russia
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- Kaplan, B (författare)
- Dept of Gynecology Petah-Tikva, Israel
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- Laron, Z (författare)
- Endocrinol and Diabetes Research Centre Petah-Tikva, Israel
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- Koskela, P (författare)
- National Public Health Oulu, Finland
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- Vesikari, T (författare)
- Dept of Virology Tampere, Finland
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- Huhtala, H (författare)
- Tampere School of Public Health Tampere, Finland
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- Knip, M (författare)
- Dept of Pediatrics Tampere, Finland
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- Hyöty, H (författare)
- Dept of Clin Microbiology Tampere, Finland
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(creator_code:org_t)
- 2005-05-19
- 2005
- Engelska.
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Ingår i: Diabetologia. - : Springer Science and Business Media LLC. - 0012-186X .- 1432-0428. ; 48:7, s. 1280-1287
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Aims/hypothesis: We have previously observed an inverse correlation between the incidence of type 1 diabetes and enterovirus infections in the background population. The aim of this study was to analyse whether maternal enterovirus antibody status, which reflects both the frequency of enterovirus infections and the protection conferred by the mother on the offspring, also correlates with the incidence of type 1 diabetes. Methods: Maternal enterovirus antibodies were analysed from serum samples taken from pregnant women between 1983 and 2001 in Finland and Sweden using enzyme immunoassay and neutralisation assays. Comparable samples were also taken between 1999 and 2001 in countries with a lower incidence of diabetes (Estonia, Germany, Hungary, Israel, Lithuania, Russia). Results: A clear decrease was observed in maternal enterovirus antibody levels over the past 20 years (p<0.0001). The frequency of enterovirus antibodies was higher in countries with a low or intermediate incidence of type 1 diabetes compared with high-incidence countries (p<0.0001). Conclusions/interpretation: These findings are in line with our previous observations supporting the hypothesis that a low frequency of enterovirus infection in the background population increases the susceptibility of young children to the diabetogenic effect of enteroviruses. © Springer-Verlag 2005.
Nyckelord
- EIA
- enterovirus
- environment
- immunity
- maternal antibody
- neutralisation assay
- population
- type 1
- diabetes
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Viskari, H
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Ludvigsson, John ...
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Uibo, R
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Salur, L
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Marciulionyte, D
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Hermann, R
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Soltesz, G
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Füchtenbusch, M
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Ziegler, A G
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Kondrashova, A
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Romanov, A
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Kaplan, B
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Laron, Z
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Koskela, P
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Vesikari, T
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Huhtala, H
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Knip, M
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Hyöty, H
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- Artiklar i publikationen
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Diabetologia
- Av lärosätet
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Linköpings universitet