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An immune risk phen...
An immune risk phenotype, cognitive impairment, and survival in very late life : Impact of allostatic load in Swedish octogenarian and nonagenarian humans
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Wikby, Anders (författare)
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Ferguson, Frederick (författare)
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Forsey, Rosalyn (författare)
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visa fler...
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Thompson, Julie (författare)
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Strindhall, Jan (författare)
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Löfgren, Sture (författare)
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Nilsson, Bengt-Olof (författare)
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- Ernerudh, Jan, 1952- (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Klinisk immunologi,Klinisk immunologi och transfusionsmedicin
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Pawelec, Graham (författare)
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Johansson, Boo (författare)
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visa färre...
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(creator_code:org_t)
- 2005
- 2005
- Engelska.
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Ingår i: The journals of gerontology. Series A, Biological sciences and medical sciences. - 1079-5006 .- 1758-535X. ; 60:5, s. 556-565
- Relaterad länk:
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https://urn.kb.se/re...
Abstract
Ämnesord
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- In the previous OCTO longitudinal study, we identified an immune risk phenotype (IRP) of high CD8 and low CD4 numbers and poor proliferative response. We also demonstrated that cognitive impairment constitutes a major predictor of nonsurvival. In the present NONA longitudinal study, we simultaneously examine in a model of allostatic load IRP and compromised cognition in 4-year survival in a population-based sample (n = 138, 86-94 years). Immune system measurements consisted of determinations of T-cell subsets, plasma interleukin 6 and cytomegalovirus and Epstein-Barr virus serology. Interleukin 2 responsiveness to concanavalin A, using data from the previous OCTO (octogenarians) immune study, hereafter OCTO immune, was also examined. Cognitive status was rated using a battery of neuropsychological tests. Logistic regression indicated that the IRP and cognitive impairment together predicted 58% of observed deaths. IRP was associated with late differentiated CD8+CD28-CD27 - cells (p < .001), decreased interleukin 2 responsiveness (p < .05) and persistent viral infection (p < .01). Cognitive impairment was associated with increased plasma interleukin 6 (p < .001). IRP individuals with cognitive impairment were all deceased at the follow-up, indicating an allostatic overload. Copyright 2005 by The Gerontological Society of America.
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- MEDICIN
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Wikby, Anders
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Ferguson, Freder ...
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Forsey, Rosalyn
-
Thompson, Julie
-
Strindhall, Jan
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Löfgren, Sture
-
visa fler...
-
Nilsson, Bengt-O ...
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Ernerudh, Jan, 1 ...
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Pawelec, Graham
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Johansson, Boo
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visa färre...
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Linköpings universitet