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Expression and grow...
Expression and growth dependency of the insulin-like growth factor I receptor in craniopharyngioma cells : A novel therapeutic approach
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Ulfarsson, Elfar (författare)
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Karström, Alexandra (författare)
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Yin, Shucheng (författare)
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- Girnita, Ada (författare)
- Karolinska Institutet
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- Vasilcanu, Daiana (författare)
- Karolinska Institutet
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- Thoren, Marja (författare)
- Karolinska Institutet
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- Kratz, Gunnar, 1963- (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Avdelningen för kirurgi,Hand- och plastikkirurgiska kliniken US
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- Hillman, Jan, 1952- (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Neurokirurgi,Neurokirurgiska kliniken US
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- Axelson, Magnus (författare)
- Karolinska Institutet
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- Larsson, Olle (författare)
- Karolinska Institutet
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- Girnita, Leonard (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2005
- 2005
- Engelska.
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Ingår i: Clinical Cancer Research. - 1078-0432 .- 1557-3265. ; 11:13, s. 4674-4680
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Craniopharyngioma is a rare benign intracranial epithelial tumor that, however, often recurs and sometimes kills the affected patients, one-third of which are children. In many cases, the patients acquire growth hormone deficiency and postoperatively need substitution. Generally, growth hormone promotes local release of insulin-like growth factor I (IGF-I), which in turn activates the IGF-I receptor (IGF-IR) if present. Together, these circumstances raise the question whether IGF-IR may be involved in craniopharyngioma growth. To address this issue, we analyzed phenotypically well-characterized primary low-passage craniopharyngioma cell lines from nine different patients for IGF-IR expression and IGF-I dependency. Two of the cell lines showed no/very low expression of the receptor and was independent on IGF-I, whereas five cell lines exhibited a strong expression and was clearly contingent on IGF-I. The two remaining cell lines had low receptor expression and IGF-I dependency. Upon treatment with an IGF-IR inhibitor, cells with high IGF-IR expression responded promptly with decreased Akt phosphorylation followed by growth arrest. These responses were not seen in cells with no/very low receptor expression. Growth of cell lines with tow IGF-IR expression was only slightly affected by IGF-IR inhibition. Taken together, our data suggest that IGF-IR may be involved in the growth of a subset of craniopharyngiomas and points to the possibility of the involvement of IGF-IR inhibitors as a treatment modality to obtain complete tumor-free conditions before growth hormone substitution. © 2005 American Association for Cancer Research.
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- MEDICINE
- MEDICIN
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Ulfarsson, Elfar
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Karström, Alexan ...
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Yin, Shucheng
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Girnita, Ada
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Vasilcanu, Daian ...
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Thoren, Marja
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Kratz, Gunnar, 1 ...
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Hillman, Jan, 19 ...
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Axelson, Magnus
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Larsson, Olle
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Girnita, Leonard
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- Artiklar i publikationen
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Clinical Cancer ...
- Av lärosätet
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Linköpings universitet
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Karolinska Institutet