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Expression and grow...
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Ulfarsson, Elfar
(författare)
Expression and growth dependency of the insulin-like growth factor I receptor in craniopharyngioma cells : A novel therapeutic approach
- Artikel/kapitelEngelska2005
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Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:liu-33241
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-33241URI
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https://doi.org/10.1158/1078-0432.CCR-05-0129DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:1953243URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Craniopharyngioma is a rare benign intracranial epithelial tumor that, however, often recurs and sometimes kills the affected patients, one-third of which are children. In many cases, the patients acquire growth hormone deficiency and postoperatively need substitution. Generally, growth hormone promotes local release of insulin-like growth factor I (IGF-I), which in turn activates the IGF-I receptor (IGF-IR) if present. Together, these circumstances raise the question whether IGF-IR may be involved in craniopharyngioma growth. To address this issue, we analyzed phenotypically well-characterized primary low-passage craniopharyngioma cell lines from nine different patients for IGF-IR expression and IGF-I dependency. Two of the cell lines showed no/very low expression of the receptor and was independent on IGF-I, whereas five cell lines exhibited a strong expression and was clearly contingent on IGF-I. The two remaining cell lines had low receptor expression and IGF-I dependency. Upon treatment with an IGF-IR inhibitor, cells with high IGF-IR expression responded promptly with decreased Akt phosphorylation followed by growth arrest. These responses were not seen in cells with no/very low receptor expression. Growth of cell lines with tow IGF-IR expression was only slightly affected by IGF-IR inhibition. Taken together, our data suggest that IGF-IR may be involved in the growth of a subset of craniopharyngiomas and points to the possibility of the involvement of IGF-IR inhibitors as a treatment modality to obtain complete tumor-free conditions before growth hormone substitution. © 2005 American Association for Cancer Research.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Karström, Alexandra
(författare)
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Yin, Shucheng
(författare)
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Girnita, AdaKarolinska Institutet
(författare)
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Vasilcanu, DaianaKarolinska Institutet
(författare)
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Thoren, MarjaKarolinska Institutet
(författare)
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Kratz, Gunnar,1963-Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Avdelningen för kirurgi,Hand- och plastikkirurgiska kliniken US(Swepub:liu)gunkr37
(författare)
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Hillman, Jan,1952-Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Neurokirurgi,Neurokirurgiska kliniken US(Swepub:liu)janhi50
(författare)
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Axelson, MagnusKarolinska Institutet
(författare)
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Larsson, OlleKarolinska Institutet
(författare)
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Girnita, LeonardKarolinska Institutet
(författare)
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Karolinska InstitutetHälsouniversitetet
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Clinical Cancer Research11:13, s. 4674-46801078-04321557-3265
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Ulfarsson, Elfar
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Karström, Alexan ...
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Yin, Shucheng
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Girnita, Ada
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Vasilcanu, Daian ...
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Thoren, Marja
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visa fler...
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Kratz, Gunnar, 1 ...
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Hillman, Jan, 19 ...
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Axelson, Magnus
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Larsson, Olle
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Girnita, Leonard
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- Artiklar i publikationen
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Clinical Cancer ...
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Linköpings universitet
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Karolinska Institutet