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Radiotherapy respon...
Radiotherapy response in oral squamous carcinoma cell lines : Evaluation of apoptotic proteins as prognostic factors
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- Roberg, Karin, 1957- (författare)
- Linköpings universitet,Oto-Rhino-Laryngologi,Hälsouniversitetet
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- Jonsson, Ann-Charlotte (författare)
- Linköpings universitet,Medicinsk radiofysik,Hälsouniversitetet
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- Grénman, Reidar (författare)
- Department of Otorhinolaryngology, Head and Neck Surgery, Central Hospital and University of Turku and Medical Biochemistry, University of Turku, Finland
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- Norberg-Spaak, Lena, 1956- (författare)
- Linköpings universitet,Oto-Rhino-Laryngologi,Hälsouniversitetet
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(creator_code:org_t)
- 2007
- 2007
- Engelska.
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Ingår i: Head and Neck. - : Wiley. - 1043-3074 .- 1097-0347. ; 29:4, s. 325-334
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background. In this study, we investigated the importance of apoptosis for cell death after radiotherapy, and whether the expression of pro- and anti-apoptotic proteins has any correlation to the radiosensitivity.Methods. Three oral squamous cell carcinoma cell lines, UT-SCC-2, UT-SCC-9 and UT-SCC-24A, were subjected to radiotherapy. After irradiation, viable and dead cells were counted to determine radiation sensitivity and apoptosis was analyzed by measurement of caspase-3 activity. The expressions of pro- and anti-apoptotic proteins were assessed using western blot analyses.Results and Conclusion. After irradiation, apoptotic morphology and caspase-3 activity were only detected in cell lines exhibiting high or moderate radiosensitivity. Western blot analysis indicates that survivin, epidermal growth factor receptor, cyclooxygenase-2, and Bcl-xL are critical components in irradiation resistance of the investigated cell lines. Moreover, our results suggest that apoptotic cell death and the balance between pro- and anti-apoptotic proteins are of importance for the outcome of radiotherapy.
Nyckelord
- Apoptosis; oral tumors; predictive markers; radiotherapy; radiosensitivity
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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