SwePub
Sök i LIBRIS databas

  Utökad sökning

onr:"swepub:oai:DiVA.org:liu-43546"
 

Sökning: onr:"swepub:oai:DiVA.org:liu-43546" > Probiotics enhance ...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004601naa a2200397 4500
001oai:DiVA.org:liu-43546
003SwePub
008091010s2008 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-435462 URI
0247 a https://doi.org/10.1152/ajpgi.00603.20072 DOI
040 a (SwePub)liu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Lutgendorff, Femke,d 1981-u Linköpings universitet,Hälsouniversitetet,Institutionen för klinisk och experimentell medicin4 aut0 (Swepub:liu)femlu88
2451 0a Probiotics enhance pancreatic glutathione biosynthesis and reduce oxidative stress in experimental acute pancreatitis
264 1b American Physiological Society,c 2008
338 a print2 rdacarrier
520 a Factors determining severity of acute pancreatitis (AP) are poorly understood. Oxidative stress causes acinar cell injury and contributes to the severity, whereas prophylactic probiotics ameliorate experimental pancreatitis. Our objective was to study how probiotics affect oxidative stress, inflammation, and acinar cell injury during the early phase of AP. Fifty-three male Sprague-Dawley rats were randomly allocated into groups: 1) control, 2) sham procedure, 3) AP with no treatment, 4) AP with probiotics, and 5) AP with placebo. AP was induced under general anesthesia by intraductal glycodeoxycholate infusion (15 mM) and intravenous cerulein (5 μg·kg-1·h-1, for 6 h). Daily probiotics or placebo were administered intragastrically, starting 5 days prior to AP. After cerulein infusion, pancreas samples were collected for analysis including lipid peroxidation, glutathione, glutamate-cysteine-ligase activity, histological grading of pancreatic injury, and NF-κB activation. The severity of pancreatic injury correlated to oxidative damage (r = 0.9) and was ameliorated by probiotics (1.5 vs. placebo 5.5, P = 0.014). AP-induced NF-κB activation was reduced by probiotics (0.20 vs. placebo 0.53 OD 450nm/mg nuclear protein, P < 0.001). Probiotics attenuated AP-induced lipid peroxidation (0.25 vs. placebo 0.51 pmol malondialdehyde/mg protein, P < 0.001). Not only was AP-induced glutathione depletion prevented (8.81 vs. placebo 4.1 μmol/mg protein, P < 0.001), probiotic pretreatment even increased glutathione compared with sham rats (8.81 vs. sham 6.18 μmol/mg protein, P < 0.001). Biosynthesis of glutathione (glutamate-cysteine-ligase activity) was enhanced in probiotic-pretreated animals. Probiotics enhanced the biosynthesis of glutathione, which may have reduced activation of inflammation and acinar cell injury and ameliorated experimental AP, via a reduction in oxidative stress. Copyright © 2008 the American Physiological Society.
653 a MEDICINE
653 a MEDICIN
7001 a Trulsson, Lena,d 1950-u Linköpings universitet,Hälsouniversitetet,Kirurgi4 aut0 (Swepub:liu)lentr38
7001 a van Minnen, L. Paulu Department of Surgery University Medical Center, Utrecht, The Netherlands4 aut
7001 a Rijkers, Ger T.u Department of Surgery University Medical Center, Utrecht, The Netherlands4 aut
7001 a Timmerman, Harro M.u Department of Surgery University Medical Center, Utrecht, The Netherlands4 aut
7001 a Franzén, Lennart E.u 3Department of Pathology and Cytology Aleris Medilab, Täby4 aut
7001 a Gooszen, Hein G.u Department of Surgery University Medical Center, Utrecht, The Netherlands4 aut
7001 a Akkermans, Louis M. A.u Department of Surgery University Medical Center, Utrecht, The Netherlands4 aut
7001 a Söderholm, Johan D,d 1958-u Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Kirurgi,Kirurgiska kliniken i Östergötland med verksamhet i Linköping, Norrköping och Motala4 aut0 (Swepub:liu)sodda63
7001 a Sandström, Per,d 1965-u Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Kirurgi,Kirurgiska kliniken i Östergötland med verksamhet i Linköping, Norrköping och Motala4 aut0 (Swepub:liu)persa07
7102 a Linköpings universitetb Hälsouniversitetet4 org
7730 t American Journal of Physiology - Gastrointestinal and Liver Physiologyd : American Physiological Societyg 295:5q 295:5x 0193-1857x 1522-1547
8564 u http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18832452
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-43546
8564 8u https://doi.org/10.1152/ajpgi.00603.2007

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy