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Recombinant human c...
Recombinant human collagen for tissue engineered corneal substitutes
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- Liu, Wenguang (författare)
- Deptartment of Cellular and Molecular Medicine University of Ottawa, Ottawa, Ontario, Canada
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- Merrett, Kimberley (författare)
- University of Ottawa Eye Institute, 501 Smyth Road, Ottawa, Ontario K1H8L6, Canada
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- Griffith, May (författare)
- Deptartment of Cellular and Molecular Medicine University of Ottawa, Ottawa, Ontario, Canada
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- Fagerholm, Per, 1948- (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Oftalmiatrik,Ögonkliniken US
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- Dravida, Subhadra (författare)
- Dravida
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- Heyne, Belinda (författare)
- Deptartment of Chemistry University of Ottawa, Ottawa, Ontario, Canada
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- Scaiano, Juan C. (författare)
- Deptartment of Chemistry University of Ottawa, Ottawa, Ontario, Canada
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- Watsky, Mitchell A. (författare)
- Deptartment of Physiology University of Tennessee Health Science Center, Memphis, TN, USA
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- Shinozaki, Naoshi (författare)
- Cornea Centre and Eye Bank Tokyo Dental College, Chiba, Japan
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- Lagali, Neil (författare)
- University of Ottawa Eye Institute, 501 Smyth Road, Ottawa, Ontario K1H8L6, Canada
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- Munger, Rejean (författare)
- University of Ottawa Eye Institute, 501 Smyth Road, Ottawa, Ontario K1H8L6, Canada
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- Li, Fengfu (författare)
- University of Ottawa Eye Institute, 501 Smyth Road, Ottawa, Ontario K1H8L6, Canada
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(creator_code:org_t)
- Elsevier BV, 2008
- 2008
- Engelska.
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Ingår i: Biomaterials. - : Elsevier BV. - 0142-9612 .- 1878-5905. ; 29:9, s. 1147-1158
- Relaterad länk:
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http://www.ncbi.nlm....
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- We successfully fabricated transparent, robust hydrogels as corneal substitutes from concentrated recombinant human type I and type III collagen solutions crosslinked with 1-ethyl-3-(3-dimethyl aminopropyl) carbodiimide (EDC) and N-hydroxysuccinimide (NHS). White light transmission through these gels is comparable or superior to that of human corneas. Hydrogels from both type I and type III collagens supported in vitro epithelium and nerve over-growth. While both these biocompatible hydrogels have adequate tensile strength and elasticity for surgical manipulation, type III collagen hydrogels tended to be mechanically superior. Twelve-month post-implantation results of type I recombinant collagen-based corneal substitutes into mini-pigs showed retention of optical clarity, along with regeneration of corneal cells, nerves and tear film. For clinical use, implants based on fully characterized, recombinant human collagen eliminate the risk of pathogen transfer or xenogeneic immuno-responses posed by animal collagens. © 2007 Elsevier Ltd. All rights reserved.
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- MEDICINE
- MEDICIN
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Liu, Wenguang
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Merrett, Kimberl ...
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Griffith, May
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Fagerholm, Per, ...
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Dravida, Subhadr ...
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Heyne, Belinda
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Scaiano, Juan C.
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Watsky, Mitchell ...
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Shinozaki, Naosh ...
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Lagali, Neil
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Munger, Rejean
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Li, Fengfu
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- Artiklar i publikationen
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Biomaterials
- Av lärosätet
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Linköpings universitet