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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03490naa a2200397 4500 | |
| 001 | oai:DiVA.org:liu-43894 | |
| 003 | SwePub | |
| 008 | 091010s2009 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:118037536 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-438942 URI |
| 024 | 7 | a https://doi.org/10.1096/fj.08-1138602 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1180375362 URI |
| 040 | a (SwePub)liud (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Zhang, Junhang,d 1968-u Karolinska Institute4 aut0 (Swepub:liu)juhzh57 |
| 245 | 1 0 | a Differential roles of PDGFR-(alpha) and PDGFR-(beta) in angiogenesis and vessel stability |
| 264 | c 2008-09-30 | |
| 264 | 1 | b Wiley,c 2009 |
| 338 | a print2 rdacarrier | |
| 520 | a Preclinical and clinical evaluations of individual proangiogenic/arteriogenic factors for the treatment of ischemic myocardium and skeletal muscle have produced unfulfilled promises. The establishment of functional and stable arterial vascular networks may require combinations of different angiogenic and arteriogenic factors. Using in vivo angiogenesis and ischemic hind-limb animal models, we have compared the angiogenic and therapeutic activities of fibroblast growth factor 2 (FGF-2) in combinations with PDGF-AA and PDGF-AB, two members of the platelet-derived growth factor (PDGF) family, with distinct receptor binding patterns. We show that both PDGF-AA/FGF-2 and PDGF-AB/FGF-2 in combinations synergistically induce angiogenesis in the mouse cornea. FGF-2 up-regulates PDGFR- and -β expression levels in the newly formed blood vessels. Interestingly, PDGF-AB/FGF-2, but not PDGF-AA/FGF-2, is able to stabilize the newly formed vasculature by recruiting pericytes, and an anti-PDGFR-β neutralizing antibody significantly blocks PDGF-AB/FGF-2-induced vessel stability. These findings demonstrate that PDGFR-β receptor is essential for vascular stability. Similarly, PDGF-AB/FGF-2 significantly induces stable collateral growth in the rat ischemic hind limb. The high number of collaterals induced by PDGF-AB/FGF-2 leads to dramatic improvement of the paw’s skin perfusion. Immunohistochemical analysis of the treated skeletal muscles confirms that a combination of PDGF-AB and FGF-2 significantly induces arteriogenesis in the ischemic tissue. A combination of PDGF-AB and FGF-2 would be optimal proangiogenic agents for the treatment of ischemic diseases.—Zhang, J., Cao, R., Zhang, Y., Jia, T., Cao, Y., Wahlberg, E. Differential roles of PDGFR- and PDGFR-βin angiogenesis and vessel stability. | |
| 653 | a neovascularization • ischemia • growth factor • receptor | |
| 653 | a MEDICINE | |
| 653 | a MEDICIN | |
| 700 | 1 | a Cao, Renhaiu Karolinska Institutet4 aut |
| 700 | 1 | a Zhang, Yunu Shandong University4 aut |
| 700 | 1 | a Jia, Tanghongu Shandong University4 aut |
| 700 | 1 | a Cao, Yihaiu Karolinska Institutet4 aut |
| 700 | 1 | a Wahlberg, Eric,d 1960-u Karolinska Institutet4 aut0 (Swepub:liu)eriwa73 |
| 710 | 2 | a Karolinska Institutetb Karolinska Institute4 org |
| 773 | 0 | t The FASEB Journald : Wileyg 23, s. 153-163q 23<153-163x 0892-6638x 1530-6860 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-43894 |
| 856 | 4 8 | u https://doi.org/10.1096/fj.08-113860 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:118037536 |
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