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IFCC guideline for ...
IFCC guideline for sampling, measuring and reporting ionized magnesium in plasma
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- Ben Rayana, Mohammed C. (författare)
- Natl Inst Nutr, Clin Chem Lab, Tunis, Tunisia
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- Burnett, Robert W. (författare)
- Hartford Hosp, Dept Pathol, Hartford, CT 06115 USA
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- Covington, Arthur K. (författare)
- Univ Newcastle Upon Tyne, Dept Chem, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
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- D'Orazio, Paul (författare)
- Instrumentat Lab, Lexington, MA USA
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- Fogh-Andersen, Niels (författare)
- Herlev Hosp, Dept Clin Biochem, Clin Chem Lab, DK-2730 Herlev, Denmark
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- Jacobs, Ellis (författare)
- NY State Dept Hlth, Wadsworth Ctr, Clin Lab Program, Albany, NY USA
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- Kulpmann, Wolf R. (författare)
- Med Hochschule, Klin Chem, Hannover, Germany
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- Kuwa, Katsuhiko (författare)
- Univ Tsukuba, Inst Clin Med, Tsukuba, Ibaraki 305, Japan
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- Larsson, Lasse (författare)
- Linköpings universitet,Hälsouniversitetet,Klinisk kemi
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- Lewenstam, Andrzej (författare)
- Abo Akad Univ, Ctr ProSens, Turku, Finland
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- Maas, Anton H. J. (författare)
- Eurotrol Bv, Ede, Netherlands
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- Mager, Gerhard (författare)
- Fresenius Med Care, Bad Homburg, Germany
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- Naskalski, Jerzy W. (författare)
- Jagiellonian Univ, Coll Med, Clin Biochem, Krakow, Poland
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(creator_code:org_t)
- 2008
- 2008
- Engelska.
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Ingår i: Clinical Chemistry and Laboratory Medicine. - 1434-6621 .- 1437-4331. ; 46:1, s. 21-26
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Analyzers with ion-selective electrodes (ISEs) for ionized magnesium (iMg) should yield comparable and unbiased results for iMg. This IFCC guideline on sampling, measuring and reporting iMg in plasma provides a prerequisite to achieve this goal [in this document, "plasma" refers to circulating plasma and the forms in which it is sampled, namely the plasma phase of anticoagulated whole blood (or "blood"), plasma separated from blood cells, or serum]. The guideline recommends measuring and reporting ionized magnesium as a substance concentration relative to the substance concentration of magnesium in primary aqueous calibrants with magnesium, sodium, and calcium chloride of physiological ionic strength. The recommended name is "the concentration of ionized magnesium in plasma". Based on this guideline, results will be approximately 3% higher than the true substance concentration and 4% lower than the true molality in plasma. Calcium ions interfere with all current magnesium ion-selective electrodes (Mg-ISEs), and thus it is necessary to determine both ions simultaneously in each sample and correct the result for Ca2+ interference. Binding of Mg in plasma is pH-dependent. Therefore, pH should be measured simultaneously with iMg to allow adjustment of the result to pH 7.4. The concentration of iMg in plasma may be physiologically and clinically more relevant than the concentration of total magnesium. Furthermore, blood-gas analyzers or instruments for point-of-care testing are able to measure plasma iMg using whole blood (with intact blood cells) as the sample, minimizing turnaround time compared to serum and plasma, which require removal of blood cells.
Nyckelord
- erythrocyte effect
- heparin
- influence factors
- interference
- ionized calcium
- ionized magnesium
- ion-selective electrode
- lipophilic anions
- liquid junction potential
- pH
- protein
- sampling
- silicone
- sodium
- MEDICINE
- MEDICIN
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Ben Rayana, Moha ...
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Burnett, Robert ...
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Covington, Arthu ...
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D'Orazio, Paul
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Fogh-Andersen, N ...
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Jacobs, Ellis
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Kulpmann, Wolf R ...
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Kuwa, Katsuhiko
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Larsson, Lasse
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Lewenstam, Andrz ...
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Maas, Anton H. J ...
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Mager, Gerhard
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Naskalski, Jerzy ...
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Linköpings universitet