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Lipid-modifying eff...
Lipid-modifying efficacy and tolerability of extended-release niacin/laropiprant in patients with primary hypercholesterolaemia or mixed dyslipidaemia
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- Maccubbin, D. (författare)
- Merck Research Laboratories, Cardiovascular Disease, Merck and Co., Inc., 126 East Lincoln Avenue, RY34A-204, Rahway, NJ 07065, United States, Merck Research Laboratories, Rahway, NJ, United States
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- Bays, H.E. (författare)
- Louisville Metabolic and Atherosclerosis Research Center, Louisville, KY, United States
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- Olsson, Anders (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Internmedicin,Endokrin- och magtarmmedicinska kliniken US
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- Elinoff, V. (författare)
- Regional Clinical Research, Inc., Endwell, NY, United States
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- Elis, A. (författare)
- Meir Hospital, Kfar Saba, Israel, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
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- Mitchel, Y. (författare)
- Merck Research Laboratories, Rahway, NJ, United States
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- Sirah, W. (författare)
- Merck Research Laboratories, Rahway, NJ, United States
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- Betteridge, A. (författare)
- Merck Research Laboratories, Rahway, NJ, United States
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- Reyes, R. (författare)
- Merck Research Laboratories, Rahway, NJ, United States
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- Yu, Q. (författare)
- Merck Research Laboratories, Rahway, NJ, United States
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- Kuznetsova, O. (författare)
- Merck Research Laboratories, Rahway, NJ, United States
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- Sisk, C.M. (författare)
- Merck Research Laboratories, Rahway, NJ, United States
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- Pasternak, R.C. (författare)
- Merck Research Laboratories, Rahway, NJ, United States
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- Paolini, J.F. (författare)
- Merck Research Laboratories, Rahway, NJ, United States
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Merck Research Laboratories, Cardiovascular Disease, Merck and Co, Inc., 126 East Lincoln Avenue, RY34A-204, Rahway, NJ 07065, United States, Merck Research Laboratories, Rahway, NJ, United States Louisville Metabolic and Atherosclerosis Research Center, Louisville, KY, United States (creator_code:org_t)
- 2008-10-20
- 2008
- Engelska.
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Ingår i: International journal of clinical practice (Esher). - : Hindawi Limited. - 1368-5031 .- 1742-1241. ; 62:12, s. 1959-1970
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Background: Improving lipids beyond low-density lipoprotein cholesterol (LDL-C) lowering with statin monotherapy may further reduce cardiovascular risk. Niacin has complementary lipid-modifying efficacy to statins and cardiovascular benefit, but is underutilised because of flushing, mediated primarily by prostaglandin D2 (PGD2). Laropiprant (LRPT), a PGD 2 receptor (DP1) antagonist that reduces niacin-induced flushing has been combined with extended-release niacin (ERN) into a fixed-dose tablet. Methods and results: Dyslipidaemic patients were randomised to ERN/LRPT 1 g (n = 800), ERN 1 g (n = 543) or placebo (n = 270) for 4 weeks. Doses were doubled (2 tablets/day, i.e. 2 g for active treatments) for 20 weeks. ERN/LRPT 2 g produced significant changes vs. placebo in LDL-C (-18.4%), high-density lipoprotein cholesterol (HDL-C, 20.0%), LDL-C:HDL-C (-31.2%), non-HDL-C (-19.8%), triglycerides (TG, -25.8%), apolipoprotein (Apo) B (-18.8%), Apo A-I (6.9%), total cholesterol (TC, -8.5%), TC:HDL-C (-23.1%) and lipoprotein(a) (-20.8%) across weeks 12-24. ERN/LRPT produced significantly less flushing than ERN during initiation (week 1) and maintenance (weeks 2-24) for all prespecified flushing end-points (incidence, intensity and discontinuation because of flushing). Except for flushing, ERN/LRPT had a safety/tolerability profile comparable with ERN. Conclusion: Extended-release niacin/LRPT 2 g produced significant, durable improvements in multiple lipid/lipoprotein parameters. The improved tolerability of ERN/LRPT supports a simplified 1 g?2 g dosing regimen of niacin, a therapy proven to reduce cardiovascular risk. © 2008 Merck & Co.
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Maccubbin, D.
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Bays, H.E.
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Olsson, Anders
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Elinoff, V.
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Elis, A.
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Mitchel, Y.
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visa fler...
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Sirah, W.
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Betteridge, A.
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Reyes, R.
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Yu, Q.
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Kuznetsova, O.
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Sisk, C.M.
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Pasternak, R.C.
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Paolini, J.F.
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Linköpings universitet