onr:"swepub:oai:DiVA.org:liu-46616"
Sökning: onr:"swepub:oai:DiVA.org:liu-46616" > Fanconi anaemia pro...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04885naa a2200553 4500 | |
| 001 | oai:DiVA.org:liu-46616 | |
| 003 | SwePub | |
| 008 | 091011s2003 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-466162 URI |
| 024 | 7 | a https://doi.org/10.1002/bies.102832 DOI |
| 040 | a (SwePub)liu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a for2 swepub-publicationtype |
| 100 | 1 | a Pagano, G.u Italian National Cancer Institute, G. Pascale Foundation, Paediatric Oncology Research Centre, Mercogliano (AV), Italy, Istituto Nazionale Tumori, Fondazione G. Pascale, v. M. Semmola, I-80131 Naples, Italy4 aut |
| 245 | 1 0 | a Fanconi anaemia proteins :b Major roles in cell protection against oxidative damage |
| 264 | c 2003-05-19 | |
| 264 | 1 | b Wiley,c 2003 |
| 338 | a print2 rdacarrier | |
| 520 | a Fanconi anaemia (FA) is a cancer-prone genetic disorder that is characterised by cytogenetic instability and redox abnormalities. Although rare subtypes of FA (B, D1 and D2) have been implicated in DNA repair through links with BRCA1 and BRCA2, such a role has yet to be demonstrated for gene products of the common subtypes. Instead, these products have been strongly implicated in xenobiotic metabolism and redox homeostasis through interactions of FANCC with cytochrome P-450 reductase and with glutathione S-transferase, and of FANCG with cytochrome P-450 2E1, as well as redox-dependent signalling through an interaction between FANCA and Akt kinase. We hypothesise that FA proteins act directly (via FANCC and FANCG) and indirectly (via FANCA, BRCA2 and FANCD2) with the machinery of cellular defence to modulate oxidative stress. The latter interactions may co-ordinate the link between the response to DNA damage and oxidative stress parameters (3, 6-12). © 2003 Wiley Periodicals, Inc. | |
| 653 | a MEDICINE | |
| 653 | a MEDICIN | |
| 700 | 1 | a Youssoufian, H.u Clinical Discovery, Bristol-Myers Squibb Company, Princeton, NJ, United States4 aut |
| 700 | 1 | a Anak, S.S.u Dept. of Paediat. Haematol./Oncolog., Istanbul Univ. School of Medicine, Istanbul, Turkey4 aut |
| 700 | 1 | a Brunk, Ulfu Linköpings universitet,Hälsouniversitetet,Farmakologi4 aut0 (Swepub:liu)ulfbr20 |
| 700 | 1 | a Calzone, R.u Department of Genetics, Elena d'Aosta Hospital, Naples, Italy4 aut |
| 700 | 1 | a Clarke, A.A.u Department of Haematology, St. George's Hosp. Medical School, University of London, London, United Kingdom4 aut |
| 700 | 1 | a Degan, P.u Italian National Cancer Institute, Genoa, Italy4 aut |
| 700 | 1 | a D'Ischia, M.u Department of Organic Chemistry, Federico II Naples University, Naples, Italy, Department of Physiology, Valencia University, Valencia, Spain4 aut |
| 700 | 1 | a Dunster, C.u Division of Life Sciences, King's College, London, United Kingdom4 aut |
| 700 | 1 | a Giudice, A.u Italian National Cancer Institute, Genoa, Italy4 aut |
| 700 | 1 | a Iaccarino, M.u Italian National Cancer Institute, Genoa, Italy4 aut |
| 700 | 1 | a Hirsch-Kauffmann, M.4 aut |
| 700 | 1 | a Kelly, F.J.u Division of Life Sciences, King's College, London, United Kingdom4 aut |
| 700 | 1 | a Lloret, A.u Department of Organic Chemistry, Federico II Naples University, Naples, Italy, Department of Physiology, Valencia University, Valencia, Spain4 aut |
| 700 | 1 | a Malorni, W.u Italian Natl. Inst. of Hlth. (ISS), Rome, Italy4 aut |
| 700 | 1 | a Manini, P.u Department of Organic Chemistry, Federico II Naples University, Naples, Italy, Department of Physiology, Valencia University, Valencia, Spain4 aut |
| 700 | 1 | a Masella, R.u Italian Natl. Inst. of Hlth. (ISS), Rome, Italy4 aut |
| 700 | 1 | a Nobili, B.u Department of Paediatrics, 2nd Naples University, Naples, Italy4 aut |
| 700 | 1 | a Pallardo, F.V.u Pallardó, F.V., Department of Organic Chemistry, Federico II Naples University, Naples, Italy, Department of Physiology, Valencia University, Valencia, Spain4 aut |
| 700 | 1 | a Schweiger, M.u Department of Biochemistry, Free University Berlin, Berlin, Germany4 aut |
| 700 | 1 | a Vuttariello, E.u Italian National Cancer Institute, Genoa, Italy4 aut |
| 700 | 1 | a Youssoufian, G.u John Whiterspoon Middle School, Princeton, NJ, United States4 aut |
| 700 | 1 | a Zatterale, A.u Department of Genetics, Elena d'Aosta Hospital, Naples, Italy4 aut |
| 710 | 2 | a Italian National Cancer Institute, G. Pascale Foundation, Paediatric Oncology Research Centre, Mercogliano (AV), Italy, Istituto Nazionale Tumori, Fondazione G. Pascale, v. M. Semmola, I-80131 Naples, Italyb Clinical Discovery, Bristol-Myers Squibb Company, Princeton, NJ, United States4 org |
| 773 | 0 | t Bioessaysd : Wileyg 25:6, s. 589-595q 25:6<589-595x 0265-9247x 1521-1878 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-46616 |
| 856 | 4 8 | u https://doi.org/10.1002/bies.10283 |
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