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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00006516naa a2200577 4500
001oai:DiVA.org:liu-47133
003SwePub
008091011s2008 | |||||||||||000 ||eng|
009oai:lup.lub.lu.se:0785375a-ac66-4a41-a675-01eca466fca0
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-471332 URI
0247 a https://doi.org/10.1016/j.eururo.2007.10.0242 DOI
0247 a https://lup.lub.lu.se/record/11405802 URI
040 a (SwePub)liud (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Streng, T.u Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Turku, Finland, Department of Clinical Chemistry and Pharmacology, Lund University Hospital, Lund, Sweden4 aut
2451 0a Distribution and Function of the Hydrogen Sulfide-Sensitive TRPA1 Ion Channel in Rat Urinary Bladder
264 1b Elsevier BV,c 2008
338 a print2 rdacarrier
520 a Objectives: To investigate the distribution of the transient receptor potential (TRP) A1 ion channel in the rat urinary bladder, and to study the effects of hydrogen sulfide (H2S) and known TRPA1 activators on micturition in conscious rats and on heterologously expressed ion channels. Methods: The expression of TRPA1 in urinary bladder was studied with fluorescence immunohistochemistry and real-time PCR in female Sprague-Dawley rats. Cystometric investigations were performed in conscious animals subjected to intravesical administration of sodium hydrogen sulfide (NaHS, donor of H2S), allyl isothiocyanate (AI), and cinnamaldehyde (CA). Fluorometric calcium imaging was used to study the effect of NaHS on human and mouse TRPA1 expressed in CHO cells. Results: TRPA1 immunoreactivity was found on unmyelinated nerve fibres within the urothelium, suburothelial space, and muscle layer as well as around blood vessels throughout the bladder. All TRPA1 immunoreactive nerves fibres also expressed TRPV1 immunoreactivity and vice versa. TRPA1 was also detected in urothelial cells at both transcriptional and protein levels. AI increased micturition frequency and reduced voiding volume. CA and NaHS produced similar changes in urodynamic parameters after disruption of the urothelial barrier with protamine sulfate. NaHS also induced calcium responses in TRPA1-expressing CHO cells, but not in untransfected cells. Conclusions: The expression of TRPA1 on C-fibre bladder afferents and urothelial cells together with the finding that intravesical TRPA1 activators initiate detrusor overactivity indicate that TRPA1 may have a role in sensory transduction in this organ. The study also highlights H2S as a TRPA1 activator potentially involved in inflammatory bladder disease. © 2007.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Urologi och njurmedicin0 (SwePub)302142 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Urology and Nephrology0 (SwePub)302142 hsv//eng
653 a Cystometry
653 a Hydrogen sulfide
653 a Micturition
653 a Rat
653 a Sensory neurons
653 a Transient receptor potential ion channels
653 a TRPA1
653 a TRPV1
653 a Urinary bladder
653 a Urothelium
653 a MEDICINE
653 a MEDICIN
7001 a Högestätt, Edwardu Lund University,Lunds universitet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine,Högestätt, E.D., Department of Clinical Chemistry and Pharmacology, Lund University Hospital, Lund, Sweden4 aut0 (Swepub:lu)kfar-eho
7001 a Hedlund, Petteru Lund University,Lunds universitet,Linköpings universitet,Klinisk farmakologi,Hälsouniversitetet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)kfar-phe
7001 a Andersson, D.A.u Wolfson Centre for Age-Related Diseases, King's College London, London, United Kingdom4 aut
7001 a Jordt, S.-E.u Department of Pharmacology, Yale University School of Medicine, New Haven, CT, United States4 aut
7001 a Bevan, S.u Wolfson Centre for Age-Related Diseases, King's College London, London, United Kingdom4 aut
7001 a Andersson, Karl-Eriku Lund University,Lunds universitet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine,Department of Clinical Chemistry and Pharmacology, Lund University Hospital, Lund, Sweden, Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC, United States4 aut0 (Swepub:lu)kfar-kea
7001 a Hogestatt, E.D.u Högestätt, E.D., Department of Clinical Chemistry and Pharmacology, Lund University Hospital, Lund, Sweden4 aut
7001 a Zygmunt, Peteru Lund University,Lunds universitet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine,Department of Clinical Chemistry and Pharmacology, Lund University Hospital, Lund, Sweden4 aut0 (Swepub:lu)kfar-pzy
7001 a Sturesson, Helenau Lund University,Lunds universitet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)klin-hax
7102 a Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Turku, Finland, Department of Clinical Chemistry and Pharmacology, Lund University Hospital, Lund, Swedenb Avdelningen för klinisk kemi och farmakologi4 org
7730 t European Urologyd : Elsevier BVg 53:2, s. 391-400q 53:2<391-400x 0302-2838x 1873-7560
8564 u http://dx.doi.org/10.1016/j.eururo.2007.10.024y FULLTEXT
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-47133
8564 8u https://doi.org/10.1016/j.eururo.2007.10.024
8564 8u https://lup.lub.lu.se/record/1140580

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